中山大学学报（医学科学版）2018，Vol.39Issue(3)：377-385,9.
症状性大脑中动脉M1段重度狭窄/闭塞患者磁共振血流信号与短期预后的关系
Correlation between Blood Flow Signal of Magnetic Resonance Imaging and Short-term Outcome in Patients with Symptomatic Severe Stenosis or Occlusion of Middle Cerebral Artery M1 segment
摘要
Abstract
[Objective] To investigatethe correlation between blood flow signal on three dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) and short-term outcome in patients with symptomatic middle cerebral artery (MCA) severe stenosis or MCA occlusion.[Methods] We retrospectively reviewed consecutive patients with symptomatic MCA severe stenosis or MCA occlusion.General information,clinical data and cranial imaging data were collected.Characteristics of blood flow signal on 3D-TOF-MRA for each patient were analyzed,which included:(1) blood flow signal of MCA distal to stenosis/occlusion lesion;(2) laterality of posterior cerebral artery (PCA).The correlation between characteristics of blood flow signal and short-term outcome was analyzed.[Results] Three hundred and twenty-eight patients were included in this study.There were 154 patients with symptomatic MCA severe stenosis and the rest of them had symptomatic MCA occlusion.Poor blood flow signal of distal MCA independently correlated with poor shortterm outcome in patients with severe MCA stenosis.[Odds Ratio (OR) 0.32,95％ Confident Interval (CI) 0.14～0.72].PCA laterality was not related with short-term outcome in these patients (OR,2.28,95％ CI,0.85～6.15).PCA laterality independently correlated with poor short-term outcome in patients with MCA occlusion.(OR,3.54,95％ CI,1.32～ 9.78).Blood flow signal of distal MCA was not related with short-term outcome in these patients (OR,0.58,95％ CI,0.22～1.48).[Conclusion] Blood flow signal on 3D-TOF-MRA correlates with short-term outcome in patients with symptomatic MCA severe stenosis or occlusion but the characteristics differs between severe MCA stenosis and occlusion patients.Anterograde blood flow (blood flow signal of MCA distal to stenosis lesion) for patients with severe MCA stenosis and retrograde blood flow (PCA laterality) for patients with MCA occlusion correlates with shot-term outcome.关键词
脑梗死/大脑中动脉/重度狭窄/闭塞/磁共振血管成像/大脑后动脉偏侧化/短期预后Key words
cerebral infarction/middle cerebral artery/severe stenosis/occlusion/magnetic resonance angiography/laterality of posterior cerebral artery/short-term outcome分类
医药卫生引用本文复制引用
束礼明,陈红兵,尚文锦,梁嘉辉,肖素,黄欣怡,洪华..症状性大脑中动脉M1段重度狭窄/闭塞患者磁共振血流信号与短期预后的关系[J].中山大学学报（医学科学版）,2018,39(3):377-385,9.基金项目
广州市科技产学研协同创新重大专项(2014Y2-00502) （2014Y2-00502）
广东省医学科学技术研究基金(A2017219) （A2017219）
广东省重大神经疾病诊治研究重点实验室(2014B030301035) （2014B030301035）
华南神经疾病早期干预及功能修复研究国际合作基地(2015B050501003) （2015B050501003）
广州市重大神经系统疾病临床医学研究与转化中心(201604020010) （201604020010）
广东省神经系统疾病重大疾病诊治工程技术研究中心(2016A030310165). （2016A030310165）
