中国现代中药2018，Vol.20Issue(5)：545-549,555,6.DOI:10.13313/j.issn.1673-4890.20171103003
黄芪及其复配组合调节正常小鼠免疫功能的探索
Study on Immune Regulating Effect of Astragalus membranaceus and Its combination on Mice
摘要
Abstract
Objective:To compare the effects of Astragalus membranaceus and its combination on mice body weight and viscera index,humoral immunity and phagocytosis of macrophages,screen A.membranaceus combination with immune regulating effect,and provide a theoretical basis for the development of related health function products.Methods:normal BALB/c mice were randomly divided into normal control group,positive drug group,Radix Astragali-Radix Glycyrrhizae A group,Radix Astragali-Radix Glycyrrhizae B group,Radix Astragali-Fructus Ligustri Lucidi A group,Astragali-Fructus Ligustri Lucidi B group,astragalus polysaccharide group.Through intragastric administration for 30 days,the mice body weight,spleen index,thymus index,the content of serum hemolysin(HC50),the phagocytic index rate of peritoneal macro-phages were measured.Results:Compared with the normal control group,the spleen index,thymus index,serum hemolysin content(HC50)and phagocytosis rate of abdominal macrophages increased in all groups.Among them,the compatibility of Radix Astragali with Radix Glycyrrhizae,Herba Cistanches and Pericarpium Citri Reticulatae increased significantly(P <0.05). Conclusion:Radix Astragali and its combination were present in the different degree to regulating normal immune function in mice,the best combination of Radix Astragali and Radix Glycyrrhizae,Herba Cistanches,Pericarpium Citri Retic-ulatae,with functions of development related health products potential.关键词
黄芪/配伍/免疫功能/血清溶血素含量/巨噬细胞吞噬率Key words
Astragalus membranaceus/compatibility/immune function/serum hemolysin content/phagocytosis rate of macrophages引用本文复制引用
王晨,于冰莉,崔洁,侯俊玲,王文全,张莉..黄芪及其复配组合调节正常小鼠免疫功能的探索[J].中国现代中药,2018,20(5):545-549,555,6.基金项目
科技部科技基础性工作专项(2015FY111500) （2015FY111500）
