北京中医药大学学报2018，Vol.41Issue(5)：405-412,8.DOI:10.3969/j.issn.1006-2157.2018.05.009
不同舌苔胃癌患者血清炎症因子表达模式研究
Expressing patterns of serum inflammatory factors in patients with gas-tric cancer with different types of tongue fur
摘要
Abstract
Objective To investigate the expressing patterns of serum inflammatory factors in patients with gastric cancer(GC)with different types of tongue fur.Methods GC patients with different types of longue fur(n=134)and non-GC subjects with different types of tongue fur(n=93)were chosen from clinic.The levels of serum inflammatory factors were detected by using electro-chemiluminescence immu-noassay(ECLIA),and correlation between types of tongue fur and serum inflammatory factors was ana-lyzed by using multi-factor association method.Results The levels of serum interleukin-17α(IL-17α) had significant difference in GC patients with different types of longue fur(P<0.05).The analysis on fur color showed that level of serum IL-17αwas 3.062 ng/L in GC patients with yellow fur and 3.982 ng/L in those with white fur(P<0.05).ROC analysis showed that the sensitivity was 72.7%,specific-ity was 91.3%and AUC(95% CI)was 0.639(0.539 -0.739)of serum IL-17αin distinguishing white fur and yellow fur,and cutoff value was 6.033 ng/L.The similar tendency was identified in non-GC subjects.The correlation analysis showed that there were 20 serum inflammatory factors with signifi-cant positive correlation in GC patients with the same types of tongue fur,and significant negative correla-tion in GC patients with different types of tongue fur.Conclusion The level of IL-17αcan significantly distinguish white tongue fur and yellow tongue fur.The white-yellow tongue fur and thin-thick tongue fur may reflect adverse inflammatory status in GC patients.关键词
胃癌/舌苔/炎症因子/表达模式Key words
gastric cancer/tongue fur/inflammatory factors/expressing patterns分类
医药卫生引用本文复制引用
张军峰,张李唯,吴娟,辛欠欠,董伟,王瑞平,詹瑧..不同舌苔胃癌患者血清炎症因子表达模式研究[J].北京中医药大学学报,2018,41(5):405-412,8.基金项目
国家自然科学基金资助项目(No.81473458,No.81473593),国家中医临床研究基地业务建设科研专项资助项目(No.JDZX2015089),江苏干部保健科研课题资助项目(No.BJ14013)National Natural Science Foundation of China(No.81473458,No.81473593),National Clinical Research Base Construction of Chinese Medi-cine of State Administration of Traditional Chinese Medicine(No.JDZX2015089),Jiangsu Geriatric Health Research(No.BJ14013) （No.81473458,No.81473593）
