南方医科大学学报2017，Vol.37Issue(3)：308-311,4.DOI:10.3969/j.issn.1673-4254.2017.03.05
系膜区IgG沉积对IgA肾病临床及病理影响
Clinical and pathological features in IgA nephropathy with IgG deposition in the glomerular mesangial area
摘要
Abstract
Objective To investigate the relationship between the clinical and pathological findings in IgA nephropathy with or without IgG deposition in the glomerular mesangial area.Methods The data were collected from 122 patients with a diagnosis of IgA nephropathy by renal biopsy in the Third Affiliated Hospital of Southern Medical University between November,2009 and February,2016.All the samples were examined by light microscopy,immunofluorescence and electron microscopy.According to the results of immunofluorescence assay,the patients were divided into IgA group (n=63) and IgA-IgG group (n=59).The pathological classification of IgA nephropathy was analyzed according to Oxford classification and Lee's classification.The clinical and pathological findings were compared between the two groups.Results Compared with the patients with IgA nephropathy but without IgG deposition,patients with IgA nephropathy with IgG deposition had higher serum creatinine,higher 24-h urine protein,higher blood uric acid,higher triglyceride levels (P＜0.05) and lower eGFR (P＜0.05);more of these patients were in Lee's grade IV-V,had renal tubular atrophy and/or interstitial fibrosis,and had MEST scores more than 3 (P＜0.05).Conclusion Patients with IgA nephropathy with IgG deposition in the glomerular mesangial have severer clinical symptoms and more serious pathological changes.Measures should be taken to control IgG deposition in patients with IgA nephropathy to delay the progress of the disease.关键词
IgA肾病/系膜区IgG沉积/Lee氏分级/牛津分级Key words
IgA nephropathy/mesangial IgG deposition/Lee's classification/Oxford classification引用本文复制引用
徐小蒙,李永强,邹和群,祝爽爽,王晓红,邵小飞,李宾,张瑛,刘琴,黎嘉敏,王红蕾..系膜区IgG沉积对IgA肾病临床及病理影响[J].南方医科大学学报,2017,37(3):308-311,4.基金项目
国家自然科学基金(81270840) （81270840）
欧盟第七框架计划资助项目(UroSense-286386) （UroSense-286386）
中国南方智谷引进创新团队和项目(CXTD-001) （CXTD-001）
广东省科技计划项目(2014A020212196) （2014A020212196）
广东省医学科研基金项目(B2013260)Supported by National Natural Science Foundation of China (81270840). （B2013260）
