南方医科大学学报2017，Vol.37Issue(5)：704-706,711,4.DOI:10.3969/j.issn.1673-4254.2017.05.24
维生素D受体基因多态性对骨关节结核易感性的影响
Association of vitamin D receptor gene polymorphisms with susceptibility to bone and joint tuberculosis in Chinese Han population
摘要
Abstract
Objective To investigate the association between vitamin D receptor (VDR) gene Apa Ⅰ polymorphism and the susceptibility to bone and joint tuberculosis in Chinese Han population.Methods Between May,2015 and June,2016,100 patients with bone and joint tuberculosis and 100 healthy volunteers were recruited concomitantly in Heyuan Hospital of Traditional Chinese Medicine.Vitamin D receptor gene Apa Ⅰ polymorphisms in these subjects were analyzed using SNaPshot.Result The genotype frequencies of Apa Ⅰ-AA,Apa Ⅰ-Aa and Apa Ⅰ-aa were 51％,41％,and 8％ in the case group and 33％,55％,and 12％ in the control group,respectively,showing significant differences between the two groups (P＜0.05).The genotype of Apa Ⅰ-AA was significantly higher in the case group with an odds ratio (OR) of 2.073 (95％ CI:1.142-3.763).Conclusion The Apa Ⅰ polymorphisms of the VDR gene are associated with the susceptibility to bone and joint tuberculosis in Chinese Han population,and individuals with a Apa Ⅰ-AA genotype are at greater risks to develop bone and joint tuberculosis.关键词
维生素D受体/基因多态性/骨关节结核Key words
Vitamin D receptor/gene polymorphism/bone and joint tuberculosis引用本文复制引用
张嘉伟,黄飘,江建明,张强,瞿东滨,林振,马学铭,钟鑫,桑朝辉,陈旭狮,宋祖坤..维生素D受体基因多态性对骨关节结核易感性的影响[J].南方医科大学学报,2017,37(5):704-706,711,4.基金项目
国家自然科学基金(81272022) Supported by National Natural Science Foundation of China (81272022). （81272022）
