南方医科大学学报2018，Vol.38Issue(5)：601-605,5.
冻融胚胎移植周期内膜转化前血清高雌二醇水平不影响妊娠结局
Effect of serum estradiol level before progesterone administration on pregnancy outcomes of frozen-thawed embryo transfer cycles
摘要
Abstract
Objective To explore whether a high serum estradiol(E2)level before progesterone administration adversely affects the pregnancy outcomes of frozen-thawed embryo transfer(FET)cycles.Methods We retrospectively analyzed 205 hormone replacement therapy(HRT)-FET cycles in our Center between February,2017 and August,2017.With a cutoff value of serum E2 level of 600 pg/mL before progesterone administration,the cases were divided into high E2level group and control group with normal E2level,and the clinical characteristics and pregnancy outcomes were compared between the two groups.Results No significant difference was found between the two groups in the patients'age during IVF/ICSI cycle,body mass index(BMI)or endometrial thickness at the time of FET(P>0.05).The patients with high E2levels had a significantly younger age(P<0.05)and a significantly longer duration of estradiol administration than those in the control group (P<0.05). The clinical pregnancy rates,ongoing pregnancy rates,early miscarriage rates,late abortion rates and live birth rates were all comparable between the two groups(P>0.05).After controlling for the compounding factors including the age at FET cycle and the duration of estradiol administration,all these pregnancy outcomes were still comparable between the two groups.Conclusion A high serum E2level before progesterone administration does not adversely affect the pregnancy outcomes of HRT-FET cycles.关键词
冻融胚胎移植/血清雌二醇/妊娠结局Key words
frozen thawed embryo transfer/serum estradiol/pregnancy outcome引用本文复制引用
邓玲,陈薪,叶德盛,陈士岭..冻融胚胎移植周期内膜转化前血清高雌二醇水平不影响妊娠结局[J].南方医科大学学报,2018,38(5):601-605,5.基金项目
国家自然科学基金(81401177) （81401177）
广东省自然科学基金(2015A030313286)Supported by National Natural Science Foundation of China(81401177). （2015A030313286）
