中国耳鼻咽喉头颈外科2017，Vol.24Issue(12)：613-616,4.DOI:10.16066/j.1672-7002.2017.12.003
耳后注射给药治疗低频下降型感音神经性聋
Treatment of low frequency decreased sensorineural hearing loss by postaural injection of Methylprednisolone
摘要
Abstract
OBJECTIVE To analyze the effect of postaural injection in treating SNHL and the influence on ROS,sVCAM-1 levels.METHODS 242 low frequency descent sensorineural hearing loss patients from Jan.2010 to Jul.2016 in our hospital were selected as the research sbjects.They were randomly divided into two groups(n=121).All patients were treated with ginkgo biloba extract intravenous drip.The control group was treated with Methylprednisolone intravenous drip,while the observation group was treated with postaural injection of Methylprednisolone.The clinical effects between the two groups were compared after 14 days of treatment.The ABR result,serum ROS,sVCAM-1 levels were also copmpared before and after treatment.RESULTS The effective rates of 2 groups were 82.64％,61.16％ respectively,which indicated significant difference (P＜0.05).The Ⅰ and Ⅴ waves of observation group were decreased,and they was significantly lower than that of the control group(P＜0.05),the R-R interval between Ⅰ and Ⅴ waves of the 2 groups showed no significant difference (P＞0.05).After treatment,the serum ROS level of 2 groups were (0.66 ± 0.38) ng/ml,(2.31± 1.12) ng/ml respectively,the sVCAM-1 level of two groups were (230.5 ±26.4) ng/ml,(312.6 ±47.2) ng/ml respectively,the observation group was significantly lower than that of the control group (t=10.985,11.953,P＜0.05).CONCLUSION Methylprednisolone can improve the clinical effect in treating low frequency descent SNHLby improving the concentration of drugs in ear and increasing the activity of Na+/K+-ATP enzyme in blood vessel;It can also decrease ROS and sVCAM-1 level,alleviate oxidative stress,reduce vascular endothelial damage,which is worthy of recommendation.关键词
听觉丧失,突发性/甲泼尼龙琥珀酸钠/临床方案/活性氧/可溶性血管细胞粘附分子-1/耳后注射Key words
Hearing Loss, Sudden/Methylprednisolone Hemisuccinate/Clinical Protocols/Reactive Oxygen Species/soluble vascular cell adhesion molecule-1/post-aural injection引用本文复制引用
成福香,岳卓立,张宇丽,张宏杰,杨波,徐涛..耳后注射给药治疗低频下降型感音神经性聋[J].中国耳鼻咽喉头颈外科,2017,24(12):613-616,4.基金项目
承德市科学技术研究与发展计划资助项目(20157076) （20157076）
