中国耳鼻咽喉头颈外科2017，Vol.24Issue(12)：629-632,4.DOI:10.16066/j.1672-7002.2017.12.007
维生素D对慢性鼻-鼻窦炎鼻内镜手术疗效的影响
Effect of Vitamin D on efficacy of endoscopic surgery for chronic rhinosinusitis
摘要
Abstract
OBJECTIVE To investigate the correlation between serum vitamin D levels and clinical efficacy of nasal endoscopic surgery for patients with chronic rhinosinusitis with nasal polyps(CRSwNP).METHODS Forty patients with CRSwNP were enrolled in this study,and were randomly divided into experimental group and control group.The experimental group were treated with VD(800 IU) plus budesonide nasal spray,and the control group was only given budesonide nasal spray for 8 weeks.Serum levels of 25-hydroxyvitamin D were measured before and after the experiment.Lund-Kennedy score,SNOT-20 and VAS were recorded.RESULTS Eighty percent of patients had VD deficiency (＜50 nmol/L)before treatment.The difference of VD level between the 2 groups was statistically significant after treatment.There was no significant difference in the scores of olfactory disorder between the 2 groups.The scores of SNOT-20 and Lund-Kennedy scores between the experimental group and the control group were statistically significant.CONCLUSION In patients with CRSwNP,the serum vitamin D levels are generally low,the clinical supplement to patients with vitamin D can significantly increase the serum levels of 25-hydroxy vitamin D,improve clinical symptoms and clinical effect of comprehensive treatment.关键词
鼻窦炎/鼻息肉/维生素D/疼痛测定/Lund-Kennedy评分/鼻腔鼻窦结局测试-20条Key words
Sinusitis/Nasal Polyps/Vitamin D/Pain Measurement/Lund-Kennedy score/sinonasal outcome test-20引用本文复制引用
房莹莹,皇甫辉,田俊,韩瑞,赵彤彤,姬晓霖..维生素D对慢性鼻-鼻窦炎鼻内镜手术疗效的影响[J].中国耳鼻咽喉头颈外科,2017,24(12):629-632,4.基金项目
国家自然科学基金资助项目(201511117) （201511117）
