中国妇幼健康研究2018，Vol.29Issue(5)：622-624,3.DOI:10.3969/j.issn.1673-5293.2018.05.021
妊娠合并梅毒患者不同治疗时期梅毒抗体滴度变化及妊娠结局研究
Changes of syphilis antibody titer and pregnancy outcome in different treatment periods of pregnant women with syphilis
摘要
Abstract
Objective To study the changes of syphilis antibody titer,timing of treatment and pregnancy outcome in different treatment periods of pregnant women with syphilis.Methods The clinical data of 101 pregnant women with syphilis who were diagnosed and treated at Maternal and Child Health Hospital of Linhai City during December 2015 to December 2016 were selected. Among them,26 patients were treated during early pregnancy,18 patients were treated during the second trimester,and 13 patients were treated during the third trimester,while 44 patients were not treated.All of the patients were tested for serum syphilis antibody.The pregnancy outcomes and the changes of serum syphilis antibody titers among four groups were compared. Results There were significant differences in the gestational weeks and neonatal outcomes among the patients in four groups(all P<0.05).In the early pregnancy treatment group,birth rate of full-term newborn was 100.00% with the highest neonatal survival rate of 100.00%,while the newborns in the untreated group were of the lowest birth rate of full-term and the lowest neonatal survival rate(both 61.36%).There was no congenital syphilis in the early pregnancy treatment group and the second trimester treatment group.There were 2 cases of congenital syphilis in the third trimester treatment group,which accounted for 18.18%(2/11).There were 11 cases of congenital syphilis in the untreated group,accounting for 40.74%(11/27)with significant differences (P=0.000).There was no significant difference in the ratio of serum tolulized red unheated serum test(TRUST)titer of patients treated in different gestational weeks(χ2= 0.183,P> 0.05).Conclusion Treating syphilis in early pregnancy can significantly improve the pregnancy outcome and prognosis of perinatal infants and reduce the incidence of congenital syphilis.关键词
妊娠/梅毒/治疗时机/血清滴度/妊娠结局Key words
pregnancy/syphilis/treatment timing/serum titer/pregnancy outcome分类
医药卫生引用本文复制引用
王彩娟,戴玲燕..妊娠合并梅毒患者不同治疗时期梅毒抗体滴度变化及妊娠结局研究[J].中国妇幼健康研究,2018,29(5):622-624,3.
