国际医学放射学杂志2018，Vol.41Issue(3)：277-281,5.DOI:10.19300/j.2018.L6081zt
钙化对FFRCT诊断冠状动脉疾病准确性影响的研究
Influence of coronary calcification on the diagnostic accuracy of FFRCTin coronary artery disease
摘要
Abstract
Objective To study the influence of coronary calcification on the diagnostic performance of fractional flow reserve(FFR)derived from coronary computed tomography angiography(CCTA)(FFRCT)in coronary artery disease. Methods CCTA and invasive coronary angiography data from 38 patients,including 50 target vessels,were retrospectively studied.The calcium scores of the 50 coronary arteries were measured by Agatston integral method,and patients were divided into two groups:A1 group(≤100)and A2 group(>100).The FFRCTvalues were measured by cFFR software.FFR derived from invasive coronary angiography and FFRCT values <0.8 were defined as lesion specific ischemia. The consistencies between FFRCTand FFR of the total,and A1 and A2 groups were calculated by using the correlation coefficient(ICC).With invasive FFR as reference standard,in a per-vessel basis,the accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of the total,and A1 and A2 groups were calculated and Fisher's exact probability method was used to compare the differences between the two groups.Results ICC coefficient of FFRCTand FFR in the whole cohort was 0.771 (95%CI:0.597~0.870),in A1 group was 0.819(95%CI:0.633~0.910),and in A2 group was 0.649(95%CI:0.032~0.873).The diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FFRCTwere 90.9%, 97.4%,96.0%,90.9%,and 97.4%,respectively for the whole cohort;85.7%,100%,96.9%,100%,and 96%,repectively,for the A1 group;and 100%,92.3%,94.1%,80%,and 100%,respectively,for the A2 group.There was no statistically significant difference in the diagnostic efficacy between the A1 and A2 groups(P>0.05).Conclusion FFRCThas good consistency with FFR in the evaluation of coronary artery stenosis.Calcification does not affect the diagnostic accuracy of FFRCT.关键词
冠心病/钙化/血流储备分数/CT血管成像/诊断效能Key words
Coronary artery disease/Calcification/Fractional flow reserve/CT angiography/Diagnostic performance分类
医药卫生引用本文复制引用
刘春雨,李建华,唐春香,周长圣,张晓蕾,陆梦洁,孙志远,卢光明,张龙江..钙化对FFRCT诊断冠状动脉疾病准确性影响的研究[J].国际医学放射学杂志,2018,41(3):277-281,5.基金项目
国家重点研发计划项目(2017YFC0113400) （2017YFC0113400）
