广西植物2018，Vol.38Issue(5)：583-589,7.DOI:10.11931/guihaia.gxzw201711014
番茄皂苷A对小鼠血脂及肝脏脂肪的作用
Effects of esculeoside A from Lycopersicon esculentum on serum lipid and liver lipid in mice
摘要
Abstract
Tomato saponin crude extract is helpful for preventing hyperlipemia. Esculeoside A is the main saponin com-pound in tomato saponin crude extract.We investigated the effects of esculeoside A on modulating levels of serum lipid,liver lipid in ApoE-deficient mice and experimental hyperlipidemia mice. Esculeoside A was administrated at a dose of 50 mg·kg-1and 100 mg·kg-1daily by gavage for 60 d to ApoE-deficient mice and experimental hyperlipidemia mice.We measured leves of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDLC),low density lipoprotein cholesterol(LDLC),alanine aminotransferases(ALT),aspartate aminotransferases(AST),blood urea ni-trogen(BUN),creatinine(Cr),glucose(Gru)in serum. The liver of each mouse was extracted,weighted and the li-ver indexes were calculated. Liver TC and TG levels were determined using a semi-automatic biochemical analyzer ac-cording to the method described in the tissue TC and TG commercial kit. The results showed that esculeoside A had no effect on levels of ALT,AST,BUN,Cr and Gru,but decreased TC,HDLC,LDLC levels in serum in ApoE-deficient mice,and had no effect on hepatic and renal functions. Esculeoside A could decreased TC and HDLC levels in serum and decreased TC levels in liver in experimental hyperlipidemia mice, and had no effect on hepatic and renal functions. It is indicated that esculeoside A can improve lipid metabolism in ApoE-deficient mice and experimental hy-perlipidemia mice,and has no effect on hepatic and renal functions.关键词
番茄/番茄皂苷A/血脂/肝脏脂肪/小鼠Key words
tomato/esculeoside A/serum lipid/liver lipid/mice分类
农业科技引用本文复制引用
张利,李典鹏,杨子明,刘金磊,黄永林,陈月圆..番茄皂苷A对小鼠血脂及肝脏脂肪的作用[J].广西植物,2018,38(5):583-589,7.基金项目
广西科技创新能力与条件建设计划项目(桂科能1598025-32) （桂科能1598025-32）
广西壮族自治区主席科技基金(16449-08) （16449-08）
广西植物研究所基本业务费项目(桂植业17007)[Supported by Guangxi Science and Technology Innovation Capability and Condition Construction Plan Program(GuiKeNeng 1598025-32) （桂植业17007）
Guangxi Zhuang Autonomous Region Chairmen Fund(16449-08) （16449-08）
Fundamental Research Foundation of Guangxi Institute of Botany(17007)]. （17007）
