解放军医学杂志2017，Vol.42Issue(9)：833-837,5.DOI:10.11855/j.issn.0577-7402.2017.09.15
自噬途径在多发性硬化发病机制中的研究进展
Autophagy and its role in the pathogenesis of multiple sclerosis
摘要
Abstract
Autophagy generally reside in eukaryote and is a highly conserved protein degradation pathway,which take part in the maintenance of cellular homeostasis as well as the growth of cells.The characterization of autophagy being reported over years has revealed that it involved in immune response,such as removal of intracellular bacteria,inflammatory cytokine secretion,antigen presentation,and lymphocyte development,and then involved in the pathogenesis of multiple sclerosis indirectly.So,in this review,we focus on the pathway ofautophagy and the role of which in the multiple sclerosis (MS) in order to further understand the important effect and potential therapeutic value of autophagy in MS.关键词
自噬/多发性硬化/免疫系统Key words
autophagy/multiple sclerosis/immune System分类
医药卫生引用本文复制引用
高晓红,原铂尧,张新燕,赵金,王满侠..自噬途径在多发性硬化发病机制中的研究进展[J].解放军医学杂志,2017,42(9):833-837,5.基金项目
甘肃省科技厅国际合作项目(1604WKCA015)This work was supported by the International Cooperation Programmer of Gansu Provincial Scientific and Techonlogy Department (1604WKCA015) （1604WKCA015）
