四川医学2018，Vol.39Issue(3)：280-283,4.DOI:10.16252/j.cnki.issn1004-0501-2018.03.009
妊娠糖尿病孕妇血清维生素D水平与妊娠结局的相关性研究
Correlation Research Between Serum Vitamin D Level and Pregnancy Outcome in Pregnant Women with Gestation-al Diabetes Mellitus
摘要
Abstract
Objective To investigate the correlation between serum 25-hydroxyvitamin D level and pregnancy outcome in pregnant women with gestational diabetes mellitus.Methods 58 pregnant women with gestational diabetes mellitus treated in our hospital from January 2015 to August 2016 were chose as gestational diabetes mellitus group,and 60 normal pregnant women in our hospital were chose as normal glucose tolerance group.According to the patients'cognitive impairment,the patients were divided into cognitive functional group and cognitive dysfunction group,comparing the biochemical indexes of the two groups.According to the pa-tients with vitamin D supplementation,the gestational diabetes mellitus group was divided into two groups,comparing the prevalence of pregnant women complications and perinatal complications in the two groups.Results The levels of FPG,FINS,C-peptide,TG3,HO-MA-β and HOMA-IR in patients in gestational diabetes mellitus group were significantly higher than those in normal glucose tolerance group,and the difference was statistically significant(P<0.05).The vitamin D level in gestational diabetes mellitus group was signifi-cantly lower than those in normal glucose tolerance group,and the difference was statistically significant(P<0.05).The vitamin defi-ciency rate in gestational diabetes mellitus group was significantly higher than that in glucose tolerance group(94.82% vs.55%),and the difference was statistically significant(P<0.05).The levels of FPG,FINS,P2HPG,HOMA-IR and HOMA-β were significantly changed after treatment;In the same treatment time,the change of biochemical index in control group was lower than that in the obser-vation group,and the difference was statistically significant(P<0.05).In the observation group,hypertension,amniotic fluid,prema-ture rupture of membranes,cesarean section and fetal distress were lower than that in the control group,and the difference was statisti-cally significant(P<0.05).Conclusion The level of serum vitamin D in gestational diabetes mellitus is lower than that in normal pregnant women,and positive vitamin D supplementation can reduce the incidence of adverse pregnancy outcomes.关键词
妊娠糖尿病/血清维生素D/妊娠结局Key words
gestational diabetes mellitus/serum vitamin d/pregnancy outcome分类
医药卫生引用本文复制引用
王丹婵,庄小瑜,郭焕仪..妊娠糖尿病孕妇血清维生素D水平与妊娠结局的相关性研究[J].四川医学,2018,39(3):280-283,4.基金项目
佛山市医学类科技公关项目(编号:2015AB000312) （编号:2015AB000312）
