四川医学2018，Vol.39Issue(5)：559-562,4.DOI:10.16252/j.cnki.issn1004-0501-2018.05.021
帕金森病伴发抑郁、焦虑状况及其相关因素调查
Research of Conditions of Parkinson′s Disease with Depression,Anxiety and Related Factors
覃冰雁 1曾丽红 1杨志 1马岸 1郭冬1
作者信息
- 1. 深圳市龙华新区人民医院,广东 深圳518109
- 折叠
摘要
Abstract
Objective To study depression,anxiety and related risk factors in Parkinson′s disease. Methods 173 cases of in patients with Parkinson′s disease were selected from February 2016 to April 2017 in our hospital. HAMD and HAMA were used to evaluate depression and anxiety, UPDRS-Ⅲ and ADL scale to evaluate daily life ability, and MMSE to assess cognitive function. Results Of the 173 patients,72 were associated with depression with the incidence of 41. 62%. 75 patients were associ-ated with anxiety with the incidence of 43. 35%. 54 patients with both depression and anxiety were found with an incidence of 31. 21%. There was no significant difference in gender,age,course of disease,onset age,MMSE score and levodopamine daily dose in patients with depression or anxiety or not(P>0. 05). Patients with depression received education years(8. 20 ± 2. 11)was sig-nificantly shorter than those of non-depressed patients, with statistically significant differences ( P <0. 05 ) . UPDRS-Ⅲ scores (28.21 ±4.33)and ADL scores(38.10 ±8.04)were significantly higher than those patients without depression with statistically significant(P<0. 05). The number of patients with anxiety was significantly smaller than that of non-depressed patients(P<0. 05) with received education years(8. 41 ± 1. 87). However,the UPDRS-Ⅲ grading score and ADL score were respectively(28. 01 ± 4. 01)and(34. 01 + 7. 62),significantly higher than those of non-anxious patients,with statistically significant difference(P<0. 05 ) . Logistic regression analysis showed that the fixed number of year of the education is the protection of the Parkinson's disease patients with depression factor(OR=0. 656),UPDRS-Ⅲ scores and ADL scores are risk factors for Parkinson's disease patients with depression(OR=1. 689 and 1. 365). The years received education is a protective factor for patients with Parkinson's disease (OR=0. 662). UPDRS-Ⅲ rating is a risk factor for Parkinson's patients comorbid anxiety(OR=1. 738). Conclusion The inci-dence of Parkinson's disease with depression and anxiety is high,and education and psychological intervention should be strength-ened in response to related risk factors.关键词
帕金森病/抑郁/焦虑/危险因素Key words
Parkinson's disease/depression/anxiety/risk factors分类
医药卫生引用本文复制引用
覃冰雁,曾丽红,杨志,马岸,郭冬..帕金森病伴发抑郁、焦虑状况及其相关因素调查[J].四川医学,2018,39(5):559-562,4.
