摘要
Abstract
Objective To investigate the efficacy of moxifloxacin in the treatment of acute exacerbation of chronic ob-structive pulmonary disease( AECOPD) . Methods 113 patients with AECOPD treated in our hospital from March 2015 to April 2017 were selected and divided into two groups according to the treatment protocol:moxifloxacin group(n=62)and levofloxacin group (n=51). The therapeutic effect,lung function,the levels of hs-CRPU,IL-8 and TNF-α,and the bacterial clearance condition were observed in the two groups. Results The total effective rate of moxifloxacin group was 79. 03%,which was better than that of levo-floxacin group(P<0. 05);In moxifloxacin group,the FEV1 and FEV1 / FVCC ratio were(2. 40 ± 0. 46)L and(70. 11 ± 7. 13)%,re-spectively,significantly higher than those in levofloxacin group ( P <0. 05 );The bacterial clearance rate of moxifloxacin group was 84. 38%,significantly higher than that of levofloxacin group(P<0. 05). There were no serious adverse reactions in both groups. Con-clusion Moxifloxacin has a good effect on AECOPD and can be used as the first choice in the treatment of AECOPD.关键词
慢性阻塞性肺疾病急性加重期/莫西沙星/左氧氟沙星/治疗疗效Key words
acute exacerbation of chronic obstructive pulmonary disease/moxifloxacin/levofloxacin/therapeutic effect分类
医药卫生
