山东医药2017，Vol.57Issue(8)：1-4,4.DOI:10.3969/j.issn.1002-266X.2017.08.001
2型糖尿病合并肝癌患者癌组织RAGE、MKK7、JNK1表达变化及意义
Expression of RAGE, MKK7 and JNK1 in patients with type 2 diabetes mellitus complicated with hepatocellular carcinoma
摘要
Abstract
Objective To investigate the expression and significance of receptor for advanced glycation end products (RAGE),mitogen-activated protein kinase kinase 7 (MKK7) and c-Jun N-terminal protein kinase 1 (JNK1) in patients with type 2 diabetes mellitus complicated with hepatocellular carcinoma.Methods The resected cancer tissues and corresponding normal tissues were obtained from 18 patients with type 2 diabetes mellitus complicated with hepatocellular carcinoma (DMHC group) and 30 patients with simple hepatocellular carcinoma (HCC group).The expression of RAGE,MKK7 and JNK1 was detected by Western blotting.The relationships of RAGE,MKK7 and JNK1 expression in the two groups with the clinical and pathological parameters of the patients were analyzed as well as the relationship among RAGE,MKK7 and JNK1.Results The expression levels of RAGE,MKK7 and JNK1 were higher in the cancer tissues of both DMHC and HCC groups than those in their corresponding adjacent normal tissues (all P ＜ 0.05).Compared with the HCC group,MKK7 and JNK1 expression in the cancer tissues of the DMHC group was higher (all P ＜ 0.05).In the HCC group,the relative expression levels of RAGE,MKK7 and JNK1 in patients with poor differentiation were higher than those in patients with high differentiation,and in the DMHC group,the relative expression levels of MKK7 and JNK1 in patients with poor differentiation were higher than those in patients with high differentiation (all P ＜ 0.05).There was a positive correlation between the expression of RAGE,MKK7 and JNK1 in the DMHC group and HCC group (all P ＜ 0.05).Conclusions The increase of RAGE expression may be involved in the occurrence and development of hepatocellular carcinoma.The expression of MKK7 and JNK1 might promote the progress of hepatocellular carcinoma in hyperglycemic state.MKK7 and JNK1 may be regulated by RAGE to some extent.关键词
肝癌/糖尿病,2型/晚期糖基化终末产物受体/丝裂原活化蛋白激酶激酶7/c-Jun氨基末端蛋白激酶1Key words
hepatocellular carcinoma/diabetes mellitus, type 2/receptor for advanced glycation end products/mitogen-activated protein kinase kinase 7/c-Jun N-terminal protein kinase 1分类
医药卫生引用本文复制引用
蒙丽恒,黄耀,徐梦婕,周嘉,李励,秦映芬..2型糖尿病合并肝癌患者癌组织RAGE、MKK7、JNK1表达变化及意义[J].山东医药,2017,57(8):1-4,4.基金项目
中华医学会临床医学科研专项资金(12020310321) （12020310321）
广西高等学校科研项目(201204LX042). （201204LX042）
