山东医药2017，Vol.57Issue(8)：5-8,4.DOI:10.3969/j.issn.1002-266X.2017.08.002
XRCC1基因Arg194Trp位点多态性与胃癌铂类药物化疗敏感性的关系
Correlation between XRCC1 gene Arg194Trp polymorphism and platinum-based chemotherapy in patients with gastric cancer
摘要
Abstract
Objective To explore the correlation between X-ray cross complementing repair gene 1 (XRCC1) gene Arg194Trp polymorphism and platinum-based chemotherapy in patients with gastric cancer.Methods Eighty patients with gastric cancer who underwent platinum-based chemotherapy were selected,and the XRCC1 genotypes were detected by multiplex PCR and ligase detection reaction (LDR).All patients were treated with oxaliplatin-based first-line chemotherapy.Accorded to the curative effect standard of gastric cancer treatment,the patients were divided into the platinum sensitive group and platinum resistance group,and the correlation between XRCC1 gene Arg194Trp polymorphism and platinumbased chemotherapy was analyzed.Results There were three kinds of genotypes in XRCC1 gene Arg194Trp:Arg/Arg,Arg/Trp,and Trp/Trp,their distribution frequencies were 42.5％ (34/80),50％ (40/80),and 7.5％ (6/80),respectively.The proportional distribution of the three genotypes met genetic equilibrium law of Hardy-Weiberg,and the experimental subjects were representative.There were no significant differences in sex,age,histological type,TNM stage,chemotherapy regimen in patients with Arg/Arg,Arg/Trp,and Trp/Trp genetypes (all P ＞ 0.05).In 80 patients,platinum drug sensitivity (CR + PR) was found in 39 patients (48.8％),and platinum drug resistance (SD + PD) in 41 patients (51.2％).The sensitivity of platinum drugs in patients with Arg/Trp and Trp/Trp genotypes was significantly higher than that in patients with Arg/Arg genotype (P ＜ 0.05),and there was no significant difference between Arg/Trp and Trp/Trp genotypes in patients (P ＞0.05).Conclusion The XRCC1 gene Arg194Trp is related with the sensitivity of platinum-based drugs in patients with gastric cancer,and the detection of Arg194Trp polymorphism can provide a basis for individual chemotherapy of gastric cancer.关键词
胃癌/X射线损伤交叉互补蛋白1/单核苷酸多态性/铂类耐药Key words
gastric carcinoma/X-ray cross complementing repair gene 1/single nucleotide polymorphism/platinum resistance分类
医药卫生引用本文复制引用
钟兰,黄涛,谢贤和,符生苗,高允锁,吴华,钟佩君..XRCC1基因Arg194Trp位点多态性与胃癌铂类药物化疗敏感性的关系[J].山东医药,2017,57(8):5-8,4.基金项目
海南省医学科研立项课题(琼卫[2012]PT-17). （琼卫[2012]PT-17）
