山东医药2017，Vol.57Issue(36)：13-16,4.DOI:10.3969/j.issn.1002-266X.2017.36.004
食管鳞癌组织PI3KCA、PI3KCB表达变化及其与患者临床病理参数的关系
Expression changes of PI3KCA and PI3KCB in esophageal squamous cell carcinoma and its relationship with clinicopathological parameters of patients
摘要
Abstract
Objective To investigate the role of PI3KCA and PI3KCB protein in the occurrence and development of esophageal squamous cell carcinoma.Methods Totally 126 cases of esophageal squamous cell carcinoma tissues,32 cases of high-grade intraepithelial neoplasia (HGIN) tissues,34 cases of low-grade intraepithelial neoplasia (LGIN) tissues,and 30 cases of normal esophageal mucosa were collected.The positive expression rate of PI3KCA and PI3KCB were detected by immunohistochemistry.The correlations between PI3KCA and PI3KCB expression and the patients' clinicopathological features were analyzed in esophageal carcinoma.Spearman analysis was used to analyze the correlations between PI3KCA and PI3KCB in the four groups.Results The expression of PI3KCA and PI3KCB in the esophageal squamous cell carcinoma tissues and HGIN tissues was significantly higher than that in the normal esophageal mucosa and LGIN tissues (both P ＜ 0.05).The expression of PI3KCA and PI3KCB was higher in patients with low degree of tumor differentiation,high TNM stage and lymph node metastasis than in patients with high degree of tumor differentiation,low TNM stage and without lymph node metastasis (both P ＜ 0.05).Other characteristics,such as age,gender,tumor size,tumor site and depth of invasion were not associated with PI3KCA and PI3KCB expression levels (all P ＞ 0.05).The expression of PI3KCA was positively correlated with PI3KCB in HGIN tissues and esophageal squamous cell carcinoma tissues (r =0.289,0.254,both P ＜ 0.05),whereas no correlation was found between PI3KCA and PI3KCB expression between LGIN tissues and normal esophageal mucosa (r =0.121,0.145,both P ＞0.05).Conclusion Both PI3KCA and PI3KCB are highly expressed in the esophageal squamous cell carcinoma,and the increased expression of PI3KCA and PI3KCB synergistically promotes the the occurrence and development of esophageal squamous cell carcinoma.关键词
食管鳞状细胞癌/上皮内瘤变/磷脂酰肌醇-3-激酶催化亚单位α/磷脂酰肌醇-3-激酶催化亚单位βKey words
esophageal squamous cell carcinoma/intraepithelial neoplasia/PI3KCA/PI3KCB分类
医药卫生引用本文复制引用
刘海青,温菲菲,李扬扬,高向前,张香芝,吴淑华..食管鳞癌组织PI3KCA、PI3KCB表达变化及其与患者临床病理参数的关系[J].山东医药,2017,57(36):13-16,4.基金项目
山东省科技发展计划项目(2010GSF10259). （2010GSF10259）
