山东医药2018，Vol.58Issue(17)：20-23,4.DOI:10.3969/j.issn.1002-266X.2018.17.006
MTHFR C667T等位点基因多态性与CHD发病的关系
Relationship between gene polymorphisms of MTHFR C667T isoforms and CHD
摘要
Abstract
Objective To investigate the relationship between gene polymorphisms of methylenetetrahydrofolate reduc -tase(MTHFR)C667T locus and the coronary artery disease(CHD).Methods Ninety-four CHD patients(CHD group) and 94 healthy volunteers(control group)were selected.We compared the systolic blood pressure(SBP),diastolic blood pressure(DBP),serum cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A(apoA), and apolipoprotein B(apoB).RT-PCR was used to detect and compare the genotype and allele frequencies of the two groups of MTHFR C 667T.Logistic regression analysis was used to analyze the risk factors of CHD.Results The CT genotype ratio of MTHFR C667T in the CHD group was higher than that of the control group(92.55%vs.76.60%,P<0.05),and the CC genotype ratio was lower than that of the control group(5.32%vs.19.15%,P<0.05).There was no significant difference in the allele frequency of C and T between the CHD group and control group(P>0.05).There was no significant difference in the levels of SBP,DBP, and apoB between the two groups(all P>0.05).Significant differences in the TC,TG,HDL-C,LDL-C,and apoA were found be-tween these two groups(all P<0.05).Multifactor Logistic regression analysis showed that genotype CT,the increased lev-els of TC,TG,LDL-C,and the decreased levels of LDL-C and apoA were the independent risk factors for CHD in the pop-ulation(all P<0.05).Conclusion The genotype CT of MTHFR C667T gene may be one of the genetic markers of ge-netic susceptibility in CHD patients,and it is also an independent risk factor for CHD.关键词
冠状动脉疾病/亚甲基四氢叶酸还原酶/基因多态性Key words
coronary artery disease/methylenetetrahydrofolate reductase/gene polymorphism分类
医药卫生引用本文复制引用
胡晨鸣,吴瑜..MTHFR C667T等位点基因多态性与CHD发病的关系[J].山东医药,2018,58(17):20-23,4.基金项目
广东省省级科技计划资助项目(2013B022000023). （2013B022000023）
