实验动物与比较医学2017，Vol.37Issue(5)：352-356,5.DOI:10.3969/j.issn.1674-5817.2017.05.003
雌二醇诱导雄性长爪沙鼠乳腺增生模型的初探
Mammary Gland Hyperplasiain Model in Male Mongolian Gerbil Induced by Estradiol
摘要
Abstract
Objective To establish mammary gland hyperplasia model in male Mongolian gerbil induced by estradiol.Methods The male Mongolian gerbils,mouse and rats were respectively ip estradiol benzoate to establish mammary gland hyperplasia model.Observe and compare the mammary gland of the experimental group with the control group.Results Histological observation showed that the mammary gland was not found in the normal male gerbils,and mammary ductal and glandular lobes were found in the male gerbils induced by estrogen.In addition,compared with mouse and rats,the gerbils showed mammary gland hyperplasia with inflammatory cells infiltration.Conclusions The mammary gland hyperplasia was successful replicated in mouse,rats and gerbils induced by estradiol benzoate,and initially demonstrated that Mongolian gerbil can be used as male mammary gland hyperplasia animal model.关键词
长爪沙鼠/雌二醇/男性乳腺发育症(GYM)Key words
Mongolian gerbil/Estradiol/Gynecomastia分类
生物科学引用本文复制引用
王存龙,杜小燕,刘欣,郭萌,吕建祎,陈振文,李长龙..雌二醇诱导雄性长爪沙鼠乳腺增生模型的初探[J].实验动物与比较医学,2017,37(5):352-356,5.基金项目
国家科技支撑计划课题(2015BAI09B01) （2015BAI09B01）
国家自然科学基金项目(31572348) （31572348）
北京自然科学基金重点项目(714100) （714100）
