实验动物与比较医学2017，Vol.37Issue(6)：470-474,5.DOI:10.3969/j.issn.1674-5817.2017.06.009
近交系CMU/1和CMU/2长爪沙鼠Willis环缺失与生理生化参数比较
Comparison on Circle of Willis Patterns, Biochemical and Physiological Characteristics of Inbred CMU/1 and CMU/2 Gerbils
摘要
Abstract
Objective To compare the ratio of the incomplete circle of Willis patterns and detect the blood biochemical and physiological indexes of 2 ischemia-prone inbred gerbil lines CMU/1 and CMU/2,and to analyze the differences between 2 strains,provide reference data for gerbils experimental application.Methods Beckman automatic biochemical analyzer (CX5) and Japan photoelectric automatic blood cell analyzer (MEK-7222K) were used to determine 17 blood biochemical parameters and 22 physiological parameters.SPSS 23.0 software was used for statistical analysis by independent samples T test.Results The ratios of incomplete circle of Willis patterns in both ischemia-prone inbred gerbil lines CMU/1 and CMU/2 were more than 76％.The 12 parameters of blood physiology and biochemistry,glucose,creatinine,triglycerides,cholesterol,platelet,mean platelet volume,basophilic granulocyte,lymphocyte％,platelet distribution width,hematocrit,mean corpuscular volume,mean Corpuscular hemoglobin,were significantly different between male and female.CMU/1 and CMU/2 were significantly different in female alanine transaminase,platelet and platelet distribution width,and high-density lipoprotein cholesterol and mean corpuscular hemoglobin in males were significantly different.There were significant differences in alkaline phosphatase,alanine transaminase and aspartate transaminase between strains.Conclusion The genotypes of ischemia-prone inbred gerbil have some impact on blood biochemical and physiological parameters.关键词
长爪沙鼠/近交系/脑缺血模型/血液生化指标/血液生理指标Key words
Gerbil/Inbred strain/Ischemia model/Biochemical index/Physiological index分类
生物科学引用本文复制引用
李迎,王冬平,陈振文,崔晓霞,杜小燕,马兰芝,尚世臣,黄斌,郭子潇,赵权,李桂军..近交系CMU/1和CMU/2长爪沙鼠Willis环缺失与生理生化参数比较[J].实验动物与比较医学,2017,37(6):470-474,5.基金项目
国家科技支撑计划课题(2015BAI09B01-04) （2015BAI09B01-04）
