实验动物与比较医学2017，Vol.37Issue(6)：491-496,6.DOI:10.3969/j.issn.1674-5817.2017.06.015
P301S突变tau转基因动物模型及其应用
P301S Mutant Tau Transgenic Mouse and Their Applications
摘要
Abstract
Microtubule associated protein tau is the major component of the intracellular filamentous deposits of several tauopathies,including Alzheimer's disease,frontotemporal dementia with Parkinsonism linked to tau mutations on chromosome 17(FTDP-17) and so on.Mutations in Tau as the cause of FTDP-17 have been identified in recent years.And transgenic animal models based on tau mutations have been established.Among these models,P301 S transgenic mouse has been widely used in the research on tauopathies.This article reviews the research progress in pathogenic manifestations of P301S mutant tau transgenic mice and their applications.关键词
P301S突变/tau蛋白/转基因小鼠/阿尔茨海默病/tau蛋白病Key words
P301S mutation/Tau protein/Transgenic mouse/Alzheimer's disease/Tauopathy分类
生物科学引用本文复制引用
马登磊,张兰..P301S突变tau转基因动物模型及其应用[J].实验动物与比较医学,2017,37(6):491-496,6.基金项目
国家自然科学基金项目(No.81473373),国家重大新药创制科技重大专项(No.2015ZX09101016001),北京市教委新医药学科群项目(No.XK100270569),北京市高层次卫生技术人才计划(No.2014-2-014) （No.81473373）
