实用医学杂志2018，Vol.34Issue(9)：1445-1449,5.DOI:10.3969/j.issn.1006-5725.2018.09.010
膈下逐瘀汤降低基质金属蛋白酶组织抑制因子的表达抑制大鼠肝纤维化形成
Infradiaphragmatic Stasis-Expelling Decoction reduce the expression of TIMP-1 contributing to inhibition of rat liver fibrosis
摘要
Abstract
Objective To investigate the protective effect and its mechanism of infradiaphragmatic stasis-expelling decoction on hepatic fibrosis in rats. Method One hundred and ten SD rats were divided into four groups:the normal control group ,model group ,low dose group and high dose group of infradiaphragmatic stasis-expelling decoction. In addition to the normal control group,rats in other groups were subcutaneously given pure CCl4 to set up the liver fibrosis model. Twelve weeks later,the serum liver biochemical indexes,including ALT,AST, ALB,TP and T-bil,the Ishak score about liver fibrosis ,the positive expression of TIMP-1 were compared among groups. Results Compared with the fibrotic group,the levels of serum ALT,AST and T-bil were lower in low dose group,the level of serum TP and ALB were increased in high dose group Levels of serum ALT,AST and T-bil were significantly lowered in high dose group,the levels of serum of TP and ALB were significantly increased in high dose group. Compared with model group,the Ishak score about liver fibrosis was significantly lowered(P<0.05). Numbers of cells with positive expression of TIMP-1 in liver tissue was reduced. Conclusion Infradiaphragmatic stasis-expelling decoction could inhibit the expression and activity of TIMP-1 contributing to the effect of antiliver fibrosis.关键词
膈下逐瘀汤/肝纤维化/基质金属蛋白酶组织抑制因子/大鼠Key words
infradiaphragmatic stasis-expelling decoction/liver fibrosis/matrix metalloproteinase1 (mmp1)/rats引用本文复制引用
张鹏,苗玉荣,曾锦荣,吴正平..膈下逐瘀汤降低基质金属蛋白酶组织抑制因子的表达抑制大鼠肝纤维化形成[J].实用医学杂志,2018,34(9):1445-1449,5.基金项目
江西省教育厅2013年度科学技术研究项目(编号:GJJ13701) （编号:GJJ13701）
