实用医学杂志2018，Vol.34Issue(9)：1504-1507,1528,5.DOI:10.3969/j.issn.1006-5725.2018.09.024
肺腺癌EGFR突变和Ki-67表达与MSCT征象的相关性
Correlation of EGFR mutations and Ki-67 expression with MSCT features in lung adenocarcinoma
摘要
Abstract
Objective To explore the correlation of EGFR and Ki-67 expressions in lung adenocarcino-ma with MSCT features and general clinical characteristics. Methods According to the differences in EGFR 19/21 gene mutation in the tumor tissues ,120 patients with lung adenocarcinoma were divided into positive group or wild type group. And Ki-67 expression in the tumor tissues was also detected. The test results were analyzed ,and the clinical data and theMSCT imaging features were examined by using the SPSS 19.0. Results The expression of EGFR differed statistically with lymphatic metastasis ,organ metastasis ,pleural indentation ,andnodule types (P < 0.05),but had no statistical significance with age ,sex ,degree of differentiation ,tumor size ,tumor-lung boundary ,burr ,lobulated sign ,vacuole sign and pleural effusion.The high expression of Ki-67 had statistical sig-nificance with lymphatic metastasis and tumor size(P < 0.05)while had no statistical significance with other in-dicators.Ki-67 expression was significantly positively correlated with EGFR(P < 0.05). Conclusions Tumor size ,pleural indentation ,lymphatic metastasis ,organ metastasis and nodular types of lung adenocarcinoma have guiding significance in judging EGFR mutation , proliferation activity ,prognosis and therapy.关键词
肺腺癌/MSCT/临床特点/EGFR/Ki-67Key words
lung adenocarcinoma/MSCT/clinical characteristics/EGFR/Ki-67引用本文复制引用
徐佳佳,张旭辉,张睿,陈晓荣..肺腺癌EGFR突变和Ki-67表达与MSCT征象的相关性[J].实用医学杂志,2018,34(9):1504-1507,1528,5.基金项目
十堰市科学技术研究与开发项目计划(编号:14Y52) （编号:14Y52）
