实用医学杂志2018，Vol.34Issue(10)：1664-1667,4.DOI:10.3969/j.issn.1006-5725.2018.10.021
妊娠晚期母体血清中性粒/淋巴细胞比值与早产发生风险相关性研究
Neutrophil-to-lymphocyte ratio as a prognostic biomarker for patients with preterm labor in late stage of pregnancy
摘要
Abstract
Objective The aim of this study was to investigate the association between maternal serum lev-el of neutrophil-lymphocyte ratio(NLR)and preterm labor in late stage of pregnancy. Methods In this retrospec-tive analysis of 200 pregnant women who underwent routine prenatal examination and delivered from January 12016 to December 312016 in the Maternal and Child Health family planning services,Xinhui District,Jiangmen city. The patients were divided into the PIR group(n = 100)and the control group(n = 100). The levels of leuko-cytes,neutrophils,lymphocytes,CRP and NLR of the two groups were compared. Multivariate analysis was per-formed to identify independent risk factor. Logistic regression model was established and the area under the receiver operating characteristic curve(ROC)was recorded for analysis of the prognostic value of different serum inflamma-tory makers in late stage of pregnancy. Results The NLR predict premature occurrence of AUC,the sensitivity and specificity of which were higher than those of peripheral blood leukocyte,neutrophil count,lymphocyte count and CRP. Conclusion Increased NLR in late stage of pregnancy could serve as an effective factor to predict the risk of preterm labor.关键词
血清中性粒/淋巴细胞比值/早产/妊娠晚期Key words
neutrophil-to-lymphocyte ratio/premature delivery/late stage of pregnancy引用本文复制引用
梁海英,夏金丝,张淼,徐若霆,黄启涛,钟梅..妊娠晚期母体血清中性粒/淋巴细胞比值与早产发生风险相关性研究[J].实用医学杂志,2018,34(10):1664-1667,4.基金项目
国家自然科学基金青年基金(编号:81401208) （编号:81401208）
广东省自然科学基金博士启动项目(编号:2015A030310025) （编号:2015A030310025）
南方医院院长基金(编号:2014B003,2016B019) （编号:2014B003,2016B019）
广东省医学科研基金(编号:A2016524) （编号:A2016524）
大学生创新创业培训计划项目(编号:201612121007) （编号:201612121007）
