物理化学学报2018，Vol.34Issue(2)：123-139,17.DOI:10.3866/PKU.WHXB201707042
纳米技术在物理刺激诱导肿瘤治疗中的应用探索
Applications of Nanotechnology for Physical Stimulus-Responsive Cancer Therapies
摘要
Abstract
Multifunctional theranostic agents that are responsive to external physical stimuli such as light, magnetic field, ultrasound, radiofrequency, and X-rays have been widely explored for their use in physical stimulus-responsive therapies for cancer. Encouraging results in many preclinical animal experiments have been obtained; thus, this innovative strategy has gained great attention. Owing to the nontoxicity of physical stimulus-responsive agents and treatment specificity under particular external stimuli, physical stimulus-responsive cancer therapies provide greatly reduced toxicity and enhanced therapeutic efficiency compared with conventional chemotherapeutic agents. When combining physical stimulus-responsive therapies with other traditional therapeutics, synergistic antitumor effects via various mechanisms can be achieved. In this review, we will summarize the recent developments in physical stimulus-responsive therapies and discuss the important roles of nanoscale theranostic agents in these novel treatment modalities.关键词
物理刺激/诊疗试剂/肿瘤治疗/多功能/联合治疗Key words
Physical stimulus-responsive/Theranostic agent/Cancer therapy/Multifunctional/Combination therapy分类
化学化工引用本文复制引用
宋雪娇,刘庄..纳米技术在物理刺激诱导肿瘤治疗中的应用探索[J].物理化学学报,2018,34(2):123-139,17.基金项目
自然科学基金委国家杰出青年基金(51525203)和科技部国家重点研发计划(2016YFA0201200)项目资助 （51525203）
The project was supported by the National Natural Science Foundation of China(51525203)and Ministry of Science and Technology(MOST)of China(2016YFA0201200). （51525203）
