物理化学学报2018，Vol.34Issue(2)：140-167,28.DOI:10.3866/PKU.WHXB201707174
多功能纳米材料在肿瘤放疗增敏中的应用
Application of Multifunctional Nanomaterials in Tumor Radiosensitization
摘要
Abstract
Radiation therapy kills tumor cells via focused high energy radiation,and has become one of the most common and effective clinical treatments for malignant tumors. However, some limitations restrict its clinical efficacy, including a requirement for elevated doses of radiation, side effects due to exposure of healthy tissue, and especially radioresistance of tumor cells. With the development of nanomedicine, multifunctional nanoradiosensitizers offer a new route to improve the efficiency of radiation therapy. In this paper, we summarize the main types of nanoradiosensitizers and their applications in radiation therapy, especially those that have currently entered clinical trials. We also summarize the main approaches to nanomaterials-based radiosensitization, and discuss the factors influencing their application. Finally, the challenges and prospects of multifunctional nanoradiosensitizers are presented.关键词
放射治疗/纳米放疗增敏剂/放疗增敏机制/纳米医学Key words
Radiation therapy/Nanoradiosensitizer/Radiosensitization mechanism/Nanomedicine分类
化学化工引用本文复制引用
龚林吉,谢佳妮,朱双,谷战军,赵宇亮..多功能纳米材料在肿瘤放疗增敏中的应用[J].物理化学学报,2018,34(2):140-167,28.基金项目
国家重点基础研究发展计划(2016YFA0201600,2016YFA0202104,2015CB932104),国家自然科学基金(31571015,11621505,11435002,21320102003)及中国科学院青年创新促进会基金(2013007)资助 （2016YFA0201600,2016YFA0202104,2015CB932104）
The project was supported by the National Basic Research Programs of China(2016YFA0201600,2016YFA0202104,2015CB932104),National Natural Science Foundation of China(31571015,11621505,11435002,21320102003)and Youth Innovation Promotion Association of Chinese Academy of Sciences(2013007). （2016YFA0201600,2016YFA0202104,2015CB932104）
