局解手术学杂志2018，Vol.27Issue(5)：329-332,4.DOI:10.11659/jjssx.01E018027
术前外周血中性粒细胞与淋巴细胞比值在预测食管癌根治术后淋巴结转移中的临床价值
Clinical value of preoperative peripheral blood neutrophil to lymphocyte ratio in predicting lymph node metasta-sis after radical resection of esophageal carcinoma
摘要
Abstract
Objective To investigate the clinical value of preoperative neutrophil to lymphocyte ratio in predicting lymph node metasta-sis after radical resection of esophageal carcinoma. Methods The clinical data of 110 patients with esophageal carcinoma who underwent radical resection of esophageal carcinoma from February 2015 to March 2017 in our hospital were retrospectively analyzed. NLR≥4 was the critical point,all patients were divided into high NLR group(NLR≥4) in 45 cases,the low NLR group(NLR<4) 65 cases,compared two groups of patients with clinical characteristics,lymph node metastasis,and regression analysis of factors influencing lymph node metastasis af-ter radical resection of esophageal carcinoma by logistic. Results There were 87 patients with lymph node metastasis in 110 cases,among which 43 cases(95. 56％) had lymph node metastasis in 45 cases of high NLR group,and 44 cases(67. 69％) had lymph node metastasis in 65 cases in low NLR group. The number of lymph node metastasis,depth of tumor invasion and distant metastasis in the high NLR group were higher than those in the low NLR group(P<0. 05),which indicated that the preoperative NLR level was related to lymph node metastasis af-ter radical resection of esophageal carcinoma. The number of lymph node metastasis and lymph node metastasis in the high NLR group were higher than those in the low NLR group(P<0. 05). The tumor T stage(OR=1. 898,95％CI:1. 151～3. 130),NLR≥4(OR=1. 919,95％CI:1. 076～3. 422) is the independent risk factors of lymph node metastasis in patients with esophageal cancer(P<0. 05). Conclusion The preoperative NLR was higher in patients with esophageal cancer and its lymph node metastasis,the greater the risk of distant metastasis tumor the deeper the infiltrating,it is more likely,to suggest it should expand the range of lymph node dissection in the operation,the lymph node metastasis,radical dissection has certain value.关键词
中性粒细胞/淋巴细胞/比值/食管癌根治术/淋巴结转移/临床价值Key words
preoperative peripheral blood neutrophil to lymphocyte ratio/lymph node metastasis after radical resection of esophageal cancer/clinical value分类
医药卫生引用本文复制引用
党杰,张永刚..术前外周血中性粒细胞与淋巴细胞比值在预测食管癌根治术后淋巴结转移中的临床价值[J].局解手术学杂志,2018,27(5):329-332,4.基金项目
陕西省自然科学基金资助项目(2014JM74024) （2014JM74024）
