中国比较医学杂志2018，Vol.28Issue(5)：12-15,4.DOI:10.3969/j.issn.1671-7856.2018.05.003
3D 细胞培养在阿尔茨海默病研究中的应用
Application of three-dimensional cell culture in the study of Alzheimer's disease
摘要
Abstract
Cells in two-dimensional(2D)cultures gradually lose their original traits as they are passaged in vitro. Existing animal models are expensive and animal experiments require too much work to conduct large-scale experiments. Three-dimensional(3D)cell culture models have attracted increasing attention as they can circumvent the limitations of these previous two models. In 2014, it was reported that the incidence of Alzheimer's disease(AD)in people over 65 years old was 5.14%. In China,the number of AD patients reached 8 million in 2016,but the pathogenesis of the disease is not yet clear. Study of AD is a 'hot' yet complicated issue. This article will briefly introduce 2D and 3D cell cultures and the application of 3D cell culture to AD research in recent years.关键词
2D细胞培养/3D细胞培养/阿尔茨海默病Key words
2D cell culture/3D cell culture/Alzheimer's disease分类
医药卫生引用本文复制引用
康美美,王蓉..3D 细胞培养在阿尔茨海默病研究中的应用[J].中国比较医学杂志,2018,28(5):12-15,4.基金项目
国家重点研发计划资助项目(编号:2016YFC1306300) （编号:2016YFC1306300）
北京市医院管理局临床医学发展专项经费(扬帆计划)(编号:ZYLX201706). （扬帆计划）
