中国比较医学杂志2018，Vol.28Issue(5)：16-20,5.DOI:10.3969/j.issn.1671-7856.2018.05.004
血管内介入方法制备非人灵长类动物局部脑缺血模型的研究进展
Research progress of focal ischemic stroke in nonhuman primates using endovascular methods
摘要
Abstract
The Stroke Therapy Academic Industry Roundtable(STAIR)committee has suggested that nonhuman primates(NHPs)should be used for preclinical stroke studies owing to previous translational failures. Ischemia induced by endovascular method closely mimics thromboembolic or thrombotic cerebrovascular occlusion in patients. This method also shows potential for endovascular treatment. This review provides a detailed summary of NHP models using endovascular method,including advantages and disadvantages,and potential applications. Additionally,we also provide further analysis based on different kinds of emboli,infract size,and abnormal hemodynamics. Selection of the optimum model will pave the way for translational research.关键词
卒中/动物模型/非人灵长类动物Key words
stroke/animal models/nonhuman primates/NHPs分类
医药卫生引用本文复制引用
吴迪,何小夺,陈健,丁玉川..血管内介入方法制备非人灵长类动物局部脑缺血模型的研究进展[J].中国比较医学杂志,2018,28(5):16-20,5.基金项目
北京市医管局青苗项目(编号:QML20170802). （编号:QML20170802）
