中国比较医学杂志2018，Vol.28Issue(5)：21-27,7.DOI:10.3969/j.issn.1671-7856.2018.05.005
帕金森疾病动物模型的研究进展
Research progress on animal models of Parkinson's disease
摘要
Abstract
Parkinson's disease(PD)is a progressive neurodegenerative disorder, with an etiology that is now considered to be due to interaction between genetic and environmental factors. Typical PD features include loss of dopaminergic neurons in the nigrostriatal region, with typical motor traits of PD associated with dopamine deficiency. Animal models have contributed to determining PD etiology and pathogenesis,as well as testing new therapeutic schedules and novel drug research. Rodents, tree shrews, primates, and other animal models of PD have been established by different method. These models each have their own advantages and limitations, showing different clinical features and pathological mechanisms to those in humans. Therefore, the appropriate model for scientific research must be carefully considered. This article reviews the main neurotoxic and transgenic models of PD.关键词
帕金森疾病/6-羟基多巴胺/1-甲基-4-苯基-1,2,3,6-四氢吡啶/神经毒素/转基因/动物模型Key words
Parkinson' s disease/PD/6-hydroxydopamine/6-OHDA/1-methyl-4-phenyl-1/2/3/6-tetrahydropyridine/MPTP/neurotoxins/transgenic/animal models分类
医药卫生引用本文复制引用
张志成,袁圆,王璇,宋庆凯,代解杰..帕金森疾病动物模型的研究进展[J].中国比较医学杂志,2018,28(5):21-27,7.基金项目
云南省科技人才和平台计划项目(编号:2017HC019) （编号:2017HC019）
云南省重点实验室运行补助专项(编号:2017DG008) （编号:2017DG008）
云南省重大科技专项(编号:2017ZF007). （编号:2017ZF007）
