中国比较医学杂志2018，Vol.28Issue(5)：53-59,7.DOI:10.3969/j.issn.1671-7856.2018.05.010
PSGL-1 通过炎症反应在小鼠盐敏感性高血压中的作用机制研究
Study on the mechanism of PSGL-1 in salt-sensitive hypertension via inflammation in mice
摘要
Abstract
Objective To investigate the role and mechanism of PSGL-1 in development of salt-sensitive hypertension in mice. Methods PSGL-1 knockout(PSGL-1 -/-)and wild type(PSGL-1 +/ +)mice were fed a high salt (6% NaCl)or normal salt(0.4% NaCl)diet for three months. Blood pressure was measured under anesthesia via the carotid artery. The status of tissue inflammation and kidney injury was tested by flow cytometry, immunohistochemistry, and western blotting. Results Compared with mice fed a normal salt diet, PSGL-1 +/ +mice fed a high salt diet for three months showed high blood pressure, increased inflammatory cell infiltration in the aorta and skin, and increased inflammatory cytokine expression(interleukin-6, interleukin-1β, and tumor necrosis factor-α)in the kidney, as well as elevated expression of the kidney injury marker, connective tissue growth factor. In contrast, inflammation and kidney injury were not found in PSGL-1 -/-mice fed a high-salt diet. Conclusions In mice,PSGL-1 via inflammation plays a key role in development of hypertension and kidney injury caused by high salt intake.关键词
PSGL-1基因/炎症反应/盐敏感性高血压/肾脏损伤Key words
PSGL-1/inflammatory responses/salt-sensitive hypertension/kidney injury分类
医药卫生引用本文复制引用
付慧,毛红亚,姜晓亮,刘星,刘雪,杨志伟..PSGL-1 通过炎症反应在小鼠盐敏感性高血压中的作用机制研究[J].中国比较医学杂志,2018,28(5):53-59,7.基金项目
国家自然科学基金面上项目(编号:81600387) （编号:81600387）
生命科学学会联合体"青年人才托举工程". （）
