中国药理学与毒理学杂志2018，Vol.32Issue(2)：135-140,6.DOI:10.3867/j.issn.1000-3002.2018.02.008
糖皮质激素受体基因甲基化在抑郁症中的作用研究进展
Research progress in glucocorticoid receptor gene methylation in depression
摘要
Abstract
Hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis and increased levels of glucocorticoid hormones are the most consistent and typical pathophysiological alternations in patients with major depression,which are possibly caused by altered functions of the receptor of glucocorticoid hormones, the glucocorticoid receptor (GR). Recent studies have found that the environmental factors interfere with the pathophysiological mechanism of depression by influencing the epigenetic regulation of glucocorticoid receptor. GR gene methylation is a way of epigenetic regulation and affects the GR expression and function of HPA axis,which plays an important role in the development of depression. In this review,domestic and foreign literature on the role of GR gene methylation in the development of depression is discussed,which will encourage provide new ideas on the diagnosis and treatment of depression.关键词
抑郁症/糖皮质激素受体/DNA甲基化Key words
depression/glucocorticoid receptor/DNA methylation分类
医药卫生引用本文复制引用
付治凤,马浩,陈春林..糖皮质激素受体基因甲基化在抑郁症中的作用研究进展[J].中国药理学与毒理学杂志,2018,32(2):135-140,6.基金项目
国家自然科学基金项目(81560584).The project supported by National Natural Science Foundation of China(81560584) （81560584）
