中国药理学与毒理学杂志2018，Vol.32Issue(2)：150-160,11.DOI:10.3867/j.issn.1000-3002.2018.02.010
细胞色素P450酶表观遗传学改变与间接致癌物致癌作用研究进展
Epigenetic changes in cytochrome P450 and indirect carcinogen carcinogenesis:a review
摘要
Abstract
Cytochrome P450(CYP450),one of the most important enzymes in the human body,medi?ates the activation and toxicity of indirect poisons as well as indirect carcinogens. CYP450 is a super?family mainly composed of CYP1A, CYP1B, CYP2A, CYP2B, CYP2C, CYP2E, CYP2W, CYP3A and their activities are widely modulated by epigenetic manners, such as DNA methylation, histone modifi?cation and microRNA interference.Indirect carcinogens including benzo(a)pyrene,2,3,7,8-tetrachlorod?ibenzo-p-dioxin,diethylstilbestrol,aflatoxin B1 and cyclophosphamide,can change epigenetic modifica?tions, such as specific changes in DNA methylation, histone acetylation, methylation or ubiquitination, and up-or down-regulation of microRNA expression,which affect the function of the major subtypes of CYP450 and their role in indirect carcinogen activation.关键词
细胞色素P450/间接致癌物/表观遗传学/致癌作用Key words
cytochrome P450/indirect carcinogen/epigenetics/carcinogenesis分类
医药卫生引用本文复制引用
刘娇凤,胡建安..细胞色素P450酶表观遗传学改变与间接致癌物致癌作用研究进展[J].中国药理学与毒理学杂志,2018,32(2):150-160,11.基金项目
国家自然科学基金项目(81372966).The project supported by National Natural Science Foundation of China(81372966) （81372966）
