中国中医药信息杂志2018，Vol.25Issue(6)：21-25,5.DOI:10.3969/j.issn.1005-5304.2018.06.006
益肾活血汤联合低频脉冲电磁场治疗脑卒中后偏瘫合并骨质疏松症临床研究
Clinical Study on Yishen Huoxue Decoction Combined with Low-Frequency Pulse Magnetic Fields for Treatment of Hemiplegia with Osteoporosis
摘要
Abstract
Objective To observe the clinical efficacy and safety of Yishen Huoxue Decoction combined with low-frequency pulse magnetic fields (PEMFs) for treatment of hemiplegia with osteoporosis (OP). Methods Totally 144 patients were divided into TCM group and control group with randomized parallel controlled method, with 72 cases in each group. Patients in control group were treated with Western routine therapy, rehabilitation training, PEMFs (putting the magnetic head on the back, five times every week, 20-30 minutes each time). On the basis of control group,TCM group received Yishen Huoxue Decoction,one dosage per day,twice a day,orally.The therapeutic course for both groups was 6 weeks. The Fugl-Meyer assessment (FMA), Barthel index (MBI), NIH stroke scale (NIHSS), and visual analogue scale (VAS) before and after treatment were observed in the two groups of patients. Bone mineral density (BMD) was measured. Blood calcium, serum phosphorus, osteocalcin (BGP) content, type 1 procollagen amino-terminal peptide (P1NP), alkaline phosphatase (BALP) were tested. Safety was tested and adverse reactions were observed. Results Compared with before treatment, the scores of FMA, MBI, NIHSS and VAS improved in both groups (P<0.05); the scores of FMA, NIHSS and VAS in the TCM group were significantly improved than the control group after treatment (P<0.05). Compared with before treatment, the levels of BMD, bone metabolic index were improved in both groups (P<0.05). The levels of BMD, BGP, BALP in the TCM group were better than the control group (P<0.05). There was no abnormality in blood routine, liver and kidney function in the 2 groups after treatment, and no obvious adverse reactions were observed. Conclusion Yishen Huoxue Decoction combined with PEMFs can enhance the motor function, improve the neurological deficit symptoms and decrease the pain in hemiplegia patients with OP, and the bone metabolism.关键词
益肾活血汤/低频脉冲电磁场/脑卒中后偏瘫/骨质疏松症Key words
Yishen Huoxue Decoction/low-frequency pulse magnetic fields/hemiplegia/osteoporosis分类
医药卫生引用本文复制引用
林惠,江兴妹,杨少梅..益肾活血汤联合低频脉冲电磁场治疗脑卒中后偏瘫合并骨质疏松症临床研究[J].中国中医药信息杂志,2018,25(6):21-25,5.基金项目
惠州市科技计划项目(2016Y089) （2016Y089）
