中国中医药信息杂志2018，Vol.25Issue(6)：73-76,4.DOI:10.3969/j.issn.1005-5304.2018.06.018
Box-Behnken效应面法优化丹皮酚纳米结构脂质载体温敏型原位凝胶处方及其体外释放性能考察
Optimization of Paeonol NLC Thermosensitive Gel Formulation by Box-Behnken Response Surface Methodology
摘要
Abstract
Objective To optimize the formulation of paeonol nanostructured lipid carrier (NLC) thermosensitive in situ gel through Box-Behnken response surface method; To investigate its release properties in vitro to provide references for the study of transdermal drug delivery system. Methods Taking mass fraction of poloxamer 407 and poloxamer 188 as the factors, the gelling temperature as the index, the mathematical relationship between the gelling temperature and two factors was established by binomial model and multivariate linear regression model. The Box-Behnken response surface method was used to optimize the formulation of paeonol NLC thermosensitive in situ gel, and the in vitro release characteristics of the preparation was investigated. Results There was a credible quantitative relationship between the gelling temperature and the 2 factors, and the binomial model was more reliable than the multivariate linear model. The best prescriptions of paeonol NLC thermosensitive in situ gel were 22.90% poloxamer 407 and 3.34% poloxamer 188; gelling temperature was (33.4±0.1)℃, and the cumulative release amount of paeonol in situ gel in 24 h was 51.19%. Conclusion This method is suitable for the formulation optimization of paeonol NLC thermosensitive in-situ gel, and the established mathematical model has good predictability. The optimized formulation can provide references for the development of paeonol transdermal preparation.关键词
温敏型原位凝胶/丹皮酚/纳米结构脂质载体/星点设计-效应面法/经皮给药Key words
in situ thermosensitive gel/paeonol/nanostructured lipid carrier/central composite design - response surface method/transdermal drug delivery分类
医药卫生引用本文复制引用
龙凯花,黄昕玥,王春柳,穆珺,李晔..Box-Behnken效应面法优化丹皮酚纳米结构脂质载体温敏型原位凝胶处方及其体外释放性能考察[J].中国中医药信息杂志,2018,25(6):73-76,4.基金项目
陕西省创新药物研究中心(2017YWZX-02) （2017YWZX-02）
