中医药学报2018，Vol.46Issue(3)：58-61,4.DOI:10.19664/j.cnki.1002-2392.180082
红树莓根茎水煎剂对昆明小鼠的急性毒性及安全性实验研究
Acute Toxicity Study and Safety Study of Raspberry Rhizome Decoction on Kunming Mice
摘要
Abstract
Objective:To study the acute toxicity and safety of raspberry rhizome decoction on Kunming mice. Methods:LD50 test of raspberry rhizome decoction was carried out at the dose of 222. 4 g/(kg·d). The general state, body weight and death of mice were observed after being given the maximum dose of 444. 8 g/(kg·d). The blood biochemical inde-xes and main viscera indexes were detected, and the pathological changes of main organs were observed. Results: It showed that the LD50 test could not be measured. The maximum dosage test showed that no death or toxicity happened in the mice, and the general condition of the mice was good. Body weight of the mice was significantly reduced only on the first day after the administration of raspberry rhizome decoction, compared to the control group(P<0. 01); but there was no significant difference between the experimental group and the control group in terms of weight gain on the fourth and seventh day(P>0. 05). There was also no significant difference between the experimental group and the control group in terms of blood biochemistry test and main organ index ( P>0 . 05 ) . The pathological examination showed no morphological changes of main organs after the administration of raspberry rhizome decoction. Conclusion: Raspberry rhizome decoction has no obvious acute toxicity to Kunming mice, which has high safety.关键词
红树莓根茎/急性毒性实验Key words
Raspberry rhizome/Acute toxicity test分类
医药卫生引用本文复制引用
孙玉珍,方毅,李书丹,于晓红..红树莓根茎水煎剂对昆明小鼠的急性毒性及安全性实验研究[J].中医药学报,2018,46(3):58-61,4.基金项目
黑龙江中医药大学校科研基金资助项目(201734) （201734）
