安徽中医药大学学报2018，Vol.37Issue(2)：22-25,4.DOI:10.3969/j.issn.2095-7246.2018.02.008
补肝益肾活血法治疗中重度斑秃临床观察
Clinical Observation of Liver-tonifying, Kidney-nourishing, and Blood-activating Method in Treatment of Moderate-to-severe Alopecia Areata
摘要
Abstract
Objective To investigate the clinical effect of liver-tonifying,kidney nourishing,and blood activating method in the treatment of moderate-to-severe alopecia areata and its effect on peripheral CD4+CD25+ regulatory T cells.Methods A total of 50 patients with moderateto-severe alopecia areata were randomly divided into treatment group and control group according to the order they visited the hospital,with 25 patients in each group.The patients in the control group were given compound glycyrrhizin tablets,and those in the treatment group were given liver-tonifying,kidney-nourishing,and blood-activating prescription.The Severity of Alopecia Tool (SALT) score was observed for both groups before and after treatment,clinical outcomes were evaluated,and flow cytometry was used to measure the changes in CD4+CD25+ regulatory T cells in peripheral serum after treatment.Results After 12 weeks of treatment,both groups had a significant reduction in SALT score (P＜0.05),and the treatment group had a significantly greater reduction than the control group (P＜0.05).There was a significant difference in the distribution of clinical outcomes between the two groups (P＜0.05).Both groups had a significant increase in the percentage of CD4+ CD25+ regulatory T cells in serum after treatment (P＜0.05),which was still lower than the normal level.Conclusion The liver-tonifying,kidney-nourishing,and blood-activating method has a good clinical effect in the treat ment of moderate-to-severe alopecia areata and can increase the percentage of peripheral CD4+ CD25+ regulatory T cells.It has a better clinical effect than compound glycyrrhizin tablets.关键词
斑秃/补肝益肾活血法/CD4/CD25/调节性T细胞Key words
Alopecia areata/Liver-tonifying, kidney-nourishing, and blood-activating method/CD4/CD25/Regulatory T cell分类
医药卫生引用本文复制引用
王建锋,刘庆婷,吴玲,张虹亚,刘涛峰..补肝益肾活血法治疗中重度斑秃临床观察[J].安徽中医药大学学报,2018,37(2):22-25,4.基金项目
安徽省自然科学基金项目(1608085QH186) （1608085QH186）
安徽中医药大学青年科研基金项目 (2013qn033) （2013qn033）
