北京生物医学工程2018，Vol.37Issue(3)：246-251,6.DOI:10.3969/j.issn.1002-3208.2018.03.005
基于功能连接的屈光参差性弱视视觉网络损伤研究
Research on visual network of anisometropic amblyopia with functional connectivity
摘要
Abstract
Objective In resting-state functional magnetic resonance imaging ( fMRI ) study, spontaneous activity patterns changed in anisometropic amblyopia could be reflected by the abnormalities of functional connectivity in visual network. Methods Twenty one adult anisometropic amblyopia and 21 normal controls participated in this study. Preprocessing with denoising and alignment, the fMRI data was analyzed to get functional connectivity value in three visual networks: the visuospatial network ( VSN ) , the high-level visual network ( HVN) and the primary visual network ( PVN) . Two sample t test was carried out to analysis functional connectivity value within the whole brain for the inter groups. Results We found a significant loss of correlation within VSN and HVN but not in PVN, and further the correlation between the VSN-HVN was also significant. Conclusions Functional connectivity is an effective noninvasive algorithm, which can help to exploring spontaneous patterns changes in amblyopia. And multiple area existed patterns abnormal and some of them may relate to the functional connectivity. These results have important implications for models of amblyopia and approaches to treatment.关键词
静息态/屈光参差性弱视/功能磁共振/功能连接Key words
resting-state/anisometropic amblyopia/functional magnetic resonance imaging ( fMRI )/functional connectivity分类
医药卫生引用本文复制引用
黄煜峰,周逸峰..基于功能连接的屈光参差性弱视视觉网络损伤研究[J].北京生物医学工程,2018,37(3):246-251,6.基金项目
国家自然科学基金(81261120562)、辽宁省教育厅科学技术研究青年项目(L201735)资助 （81261120562）
