长春中医药大学学报2018，Vol.34Issue(3)：439-442,4.DOI:10.13463/j.cnki.cczyy.2018.03.010
柴胡疏肝散对代谢综合征大鼠抗动脉硬化的作用机制
Effect and mechanism study of Chaihu Shugan powder on anti-arteriosclerosis in rats with metabolic syndrome
摘要
Abstract
Objective To observe the effect and mechanism study of Chaihu Shugan powder on anti-arteriosclerosis in rats with metabolic syndrome(MS).Methods The rat model with MS was induced by high fat sugar and high salt diet (8 weeks), then they were fed by way of gavage with drugs for 4 weeks. The levels of weight, lipid, systolic blood pressure of arteria caudilis (SBP), fast blood glucose (FBG), superoxide dismutase (SOD), malondialdehyde (MDA), matrix metalloproteinase-9(MMP-9), tissue inhibitor of metalloproteinase-1(TIMP-1) were measured at the eighth and twelfth week, morphological changes of thoracic aorta were detected by hematoxylin eosin (HE) staining.Results Compared with the blank group,the weight, lipid, SBP, FBG, MDA, MMP-9 of rats in the model group increased significantly (P<0.05), while SOD, TIMP-1 decreased significantly (P<0.05), tatherosclerotic plaques was formed. Compared with the model group, the weight, lipid, SBP, FBG, MDA, MMP-9 of rats in Chaihu Shugan powder group decreased significantly (P<0.05),while SOD,TIMP-1 increased significantly (P<0.05), and the plaques reduced significantly (P<0.05).Conclusion Chaihu Shugan powder could delay the progression of metabolic syndrome- atherosclerosis by inhibiting the expression of MMP-9 and MDA and promoting the expression of SOD and TIMP-1.关键词
柴胡疏肝散/代谢综合征/大鼠/动脉硬化Key words
Chaihu Shugan powder/metabolic syndrome/rats/arteriosclerosis分类
医药卫生引用本文复制引用
林黄果,刘淑玲,赵帅,陈伯钧..柴胡疏肝散对代谢综合征大鼠抗动脉硬化的作用机制[J].长春中医药大学学报,2018,34(3):439-442,4.基金项目
国家自然科学基金委员会面上项目(81273961) （81273961）
广东省中医药局科研基金(20151207). （20151207）
