长春中医药大学学报2018，Vol.34Issue(3)：508-511,4.DOI:10.13463/j.cnki.cczyy.2018.03.031
补阳还五汤胶囊制剂对症状性颅内大动脉狭窄患者脑血流储备的影响
Effect of Buyang Huanwu decoction capsule on cerebrovascular reserve in patients with intracranial large artery stenosis
摘要
Abstract
Objective To study of the effect of Buyang huanwu decoction capsules (Thrombolytic enteric-coated capsules) on cerebrovascular reserve in patients with intracranial large artery stenosis (sICAS ).Methods 60 patients with sICAS were randomly divided into trial group (n=30) and control group (n=30) according to random number table method. The control group was given oral aspirin enteric-coated tablets 100 mg (qd) and simvastatin tablets 20 mg (qd). On the basis of this, the test group was supplemented with two tablets of Thrombolytic enteric-coated capsule (tid). Both groups were treated for 3 months. The general indexes, blood flow reserve, NIHSS score, cerebrovascular events and hs-CRP, MMP-9, SOD and MDA contents were measured before and after treatment.ResultsThe total effective rate in the observation group was 96.9％, which was higher than that in the control group (89.5％) (P<0.05). Compared with the control group, the blood flow reserve was significantly increased (P<0.05), the NIHSS score was significantly decreased (P<0.05), hs- CRP, MMP-9 content was significantly decreased (P<0.05), SOD content was increased significantly (P<0.05) and MDA content was significantly decreased (P<0.05).Conclusion Buyang Huanwu detection capsule (Thrombolytic enteric-coated capsule) has a certain therapeutic effect on sICAS, which can significantly improve the vascular environment and reduce brain cell damage, and ease sICAS progress.关键词
补阳还五汤/消栓肠溶胶囊/症状性颅内大动脉狭窄Key words
Buyang Huanwu detection/Thrombolytic Enteric-coated capsule/symptomatic intracranial artery stenosis分类
医药卫生引用本文复制引用
秦劭晨,王爱梅,马阮昕,夏天,郑秀利..补阳还五汤胶囊制剂对症状性颅内大动脉狭窄患者脑血流储备的影响[J].长春中医药大学学报,2018,34(3):508-511,4.基金项目
山西省卫生和计划生育委员会科研课题(201601119). （201601119）
