福建农业学报2018，Vol.33Issue(4)：337-340,4.
伪狂犬病病毒(PRV)不同毒株抗原相关性研究
Study on Antigen Correlation of Different PRV Strains
摘要
Abstract
Antigenicity difference among strains of pseudorabies virus (PRV) and potential of developing a vaccine to prevent new PRV from occurring were studied .Four PRV strains (i .e .,PRV FB ,FA ,Bartha-K61 and prevalent PRV-FJ2012) and hyperimmune serums were used for the analysis by a cross neutralization test .The possibility of using PRV-FB to develop a vaccine was evaluated by a challenge test .The neutralization titers of hyperimmune serum for rabbit anti-FB ,anti-FA ,anti-Bartha-K61 and anti-FJ2012 were 1 : 54 ,1: 91 ,1: 91 ,and 1 : 215 , respectively .The correlation coefficients between FB and FA ,FB and FJ2012 ,and FA and FJ2012 were all greater than 0.8. However ,those between Bartha-K61 and FA ,Bartha-K61 and FB ,and Bartha-K61 and FJ2012 were lower than 0.4 .The results indicated that the relationship between the antigens of FB and FJ2012 was closer than that of Bartha-K61 and FJ2012. The viral challenge test showed that FB could prevent PRV-FJ2012 at a rate of 100％ .These conclusion indicated FB strain was a vaccine candidate strain to prevent the new PRV strain(FJ2012 strain) .关键词
伪狂犬病病毒(PRV)/FA株/FB株/Bartha-K61株/FJ2012株/抗原相关性/免疫保护Key words
pseudorabies virus (PRV )/FA strain/FB strain/Bartha-K61 strain/FJ2012 strain/antigen correlation/immune protection分类
农业科技引用本文复制引用
程晓霞,车勇良,王劭,肖世峰,朱小丽,陈仕龙,林锋强,陈少莺,周伦江..伪狂犬病病毒(PRV)不同毒株抗原相关性研究[J].福建农业学报,2018,33(4):337-340,4.基金项目
福建省科技计划项目——省属公益类科研院所基本科研专项 (2015R1023-17、2015R1023-16) （2015R1023-17、2015R1023-16）
