法医学杂志2018，Vol.34Issue(2)：132-137,6.DOI:10.3969/j.issn.1004-5619.2018.02.005
基于SNP位点的身高预测模型的评估
Assessment of Height Prediction Model Based on SNPs Loci
摘要
Abstract
Objective To establish a height prediction model of Chinese Han male based on the reported 547 height-associated single nucleotide polymorphisms (SNPs) loci in Europeans, and assess its accuracy for height estimation. Methods The DNA typing was analyzed in 59 Han male samples of Shandong province by Affymetrix SNP Array 6.0 chip and HiSeq 4000 sequencing platform. Prediction model was established using 547 height-associated SNPs loci as predictors and weight allele sums (WAS) as com-puting method. The accuracy of height prediction model was analysed using receiver operating characteris-tic (ROC) curve and area under curve (AUC). Results There was no height-associated SNPs locus was found by genome-wide association studies. In present study, height prediction model was established by WAS and obtained an AUC of 0.67 (95％CI:0.53-0.90). Conclusion It has reference value for predicting the height of Han male in Shandong province by WAS model based on 547 SNPs loci, while it is still necessary to further promote the accuracy of the prediction model by screening more height-associated SNPs loci with population heterogeneity.关键词
法医遗传学/法医人类学/单核苷酸多态性/身高/预测/汉族Key words
forensic genetics/forensic anthropology/single nucleotide polymorphism/body height/fore-casting/Han nationality分类
社会科学引用本文复制引用
焦会永,赵雯婷,孙亚男,景晓溪,刘京,江丽,李彩霞,叶健,刘凡,黄艳梅..基于SNP位点的身高预测模型的评估[J].法医学杂志,2018,34(2):132-137,6.基金项目
国家自然科学基金资助项目(81471828) （81471828）
国家重点研发计划资助项目(2017YFC0803501) （2017YFC0803501）
国家科技资源共享服务平台计划资助项目(YCZYPT[2017]01-3) （YCZYPT[2017]01-3）
中央级公益性科研院所基本科研业务费专项资金资助项目(2017JB025) （2017JB025）
法医遗传学公安部重点实验室开放课题资助项目(2017FGKFKT06) （2017FGKFKT06）
