国际神经病学神经外科学杂志2018，Vol.45Issue(2)：120-123,4.DOI:10.16636/j.cnki.jinn.2018.02.004
硫辛酸对慢性酒精性周围神经病炎性因子及临床症状的影响
Effect of lipoic acid on inflammatory factors and clinical symptoms of chronic alcoholic peripheral neuropathy
蒲晓龙 1温慧军2
作者信息
- 1. 宝鸡市人民医院神经内二科,陕西省宝鸡市721000
- 2. 宝鸡市中心医院神经内科,陕西省宝鸡市721008
- 折叠
摘要
Abstract
Objective To investigate the effect of lipoic acid on inflammatory factors and clinical symptoms in patients with chronic alcoholic peripheral neuropathy (CAPN).Methods A total of 42 CAPN patients who visited Department of Neurology in Baoji Central Hospital were enrolled and randomly divided into treatment group and control group,with 21 patients in each group.The patients in the treatment group were given intravenous drip of lipoic acid 0.6 g/d,and those in the control group were given intravenous drip of mecobalamin injection 500 μg/d in the dark.The course of treatment was 2 weeks for both groups.The two groups were compared in terms of the changes in tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and the improvement in clinical symptoms after treatment.Results Both groups had significant reductions in the levels of TNF-α and IL-6 after treatment (P ＜ 0.05),and the treatment group had significantly lower levels than the control group (P ＜ 0.05).Both groups had a significant reduction in clinical symptom score after treatment (P ＜ 0.05),and the treatment group had a significantly lower score than the control group (P ＜ 0.05).Conclusions Lipoic acid can reduce the expression of inflammatory factors in CAPN patients and significantly improve their clinical symptoms.Therefore,it holds promise for clinical application and research.关键词
硫辛酸/慢性酒精性周围神经病/炎症因子/临床症状Key words
lipoic acid/chronic alcoholic peripheral neuropathy/inflammatory factor/clinical symptom引用本文复制引用
蒲晓龙,温慧军..硫辛酸对慢性酒精性周围神经病炎性因子及临床症状的影响[J].国际神经病学神经外科学杂志,2018,45(2):120-123,4.
