海南医学院学报2018，Vol.24Issue(8)：829-832,4.DOI:10.13210/j.cnki.jhmu.20180411.003
慢性心衰患者血清Ang-2含量与神经体液指标、心肌重构指标的相关性研究
The correlation of serum Ang-2 level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure
摘要
Abstract
Objective:To study the correlation of serum angiogenin 2 (Ang-2) level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure.Methods:The patients with chronic heart failure who were treated in the People's Hospital of Huangmei between March 2015 and October 2017 were selected and divided into NYHA Ⅰ-Ⅱ group and NYHA Ⅲ-Ⅳ group according to cardiac function classification;healthy subjects who received physical examination during the same period were selected as the control group.The levels of Ang-2,neurohumor indexes and myocardial remodeling indexes in serum were determined.Results:Serum Ang-2,NT-proBNP,Copeptin,ET-1,AT-Ⅱ,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels of NYHA Ⅰ-Ⅱ group and NYHA Ⅲ-Ⅳ group were significantly higher than those of control group whereas TIMP4 levels were significantly lower than that of control group;serum Ang-2,NT-proBNP,Copeptin,ET-1,AT-Ⅱ,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels of NYHA Ⅲ-Ⅳ group were significantly higher than those of NYHA Ⅰ-Ⅱ group whereas TIMP4 level was significantly lower than that of NYHA Ⅰ-Ⅱ group.Serum NT-proBNP,Copeptin,ET-1,AT-Ⅱ,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels in chronic heart failure patients with high Ang2 level were significantly higher than those in chronic heart failure patients with low Ang-2 level whereas TIMP4 level was significantly lower than that in chronic heart failure patients with low Ang-2 level.Conclusion:The increase of Ang-2 in patients with chronic heart failure is related to neurohumoral disorder and myocardial remodeling aggravation.关键词
慢性心力衰竭/血管生成素-2/神经体液/心肌重构Key words
Chronic heart failure/Angiogenin-2/Neurohumor/Myocardial remodeling分类
医药卫生引用本文复制引用
石成虎,柏忠美,胡风涛..慢性心衰患者血清Ang-2含量与神经体液指标、心肌重构指标的相关性研究[J].海南医学院学报,2018,24(8):829-832,4.基金项目
This study was supported by Hubei Provincial Health Planning Commission Medical College Scientific Research Project (grant No.WJ2016-Y2-11).湖北省卫计委医药院校科研项目(WJ2016-Y2-11) （grant No.WJ2016-Y2-11）
