海南医学院学报2018，Vol.24Issue(8)：833-836,4.DOI:10.13210/j.cnki.jhmu.20180116.004
利拉鲁肽联合二甲双胍对T2DM合并肥胖患者脂代谢及微炎症反应的影响
Effects of liraglutide combined with metformin on lipid metabolism and micro-inflammatory response in T2DM patients with obesity
摘要
Abstract
Objective:To investigate the effects of liraglutide combined with metformin on lipid metabolism and microinflammatory response in T2DM patients with obesity.Methods:138 T2DM patients with obesity who were treated in the hospital between May 2016 and August 2017 were divided into control group (n =69) and liraglutide group (n =69) by random number table method.Control group received metformin therapy and liraglutide group received liraglutide combined with metformin therapy,which lasted for 3 months.The differences in the levels of insulin resistance indexes,cholesterol-related indexes,apolipoprotein and inflammatory mediators were compared between the two groups.Results:After 3 months of treatment,serum insulin resistance-related indexes FBG and FINS levels of liraglutide group were lower than those of control group;serum cholesterol-related indexes TC and LDL-C contents were lower than those of control group whereas HDL-C content was higher than that of control group;serum apolipoprotein Apo A Ⅰ and Apo A Ⅱ contents were higher than those of control group whereas Apo C Ⅱ and Apo CⅢ contents were lower than those of control group;serum inflammatory mediators IL-6,IL-17 and TNF-α contents were lower than those of control group.Conclusion:Metformin combined with liraglutide therapy can further optimize the glycolipid metabolism and inhibit the micro-inflammatory state in T2DM patients with obesity.关键词
T2DM/利拉鲁肽/二甲双胍/脂代谢/微炎症Key words
T2DM/Liraglutide/Metformin/ipid metabolism/Micro-inflammation分类
医药卫生引用本文复制引用
张卫欢,李晓庆,王珊,李秋云,周艳茹,刘星,王倩,郭智慧,杨春伟,王婷婷,何桦..利拉鲁肽联合二甲双胍对T2DM合并肥胖患者脂代谢及微炎症反应的影响[J].海南医学院学报,2018,24(8):833-836,4.基金项目
It is supported by Key Project of Medicine Research of Hebei Province (20160758).河北省医学科学研究重点课题编号:20160758 （20160758）
