海南医学院学报2018，Vol.24Issue(8)：841-844,848,5.DOI:10.13210/j.cnki.jhmu.20180119.003
厄贝沙坦氢氯噻嗪对高血压患者血管内皮功能、血流动力学及炎症反应的影响
Effect of irbesartan hydrochlorothiazide on endothelial function, hemodynamics and inflammatory response in hypertensive patients
摘要
Abstract
Objective:To observe the effect of irbesartan hydrochloride on endothelial function,hemodynamics and inflammatory response in patients with essential hypertension.Method:A total of 100 patients with essential hypertension admitted from May 2015 to August 2017 in our hospital were divided into observation group (n =50) and control group (n =50) according to random number table.Thecontrol group was treated with routine treatment,and the observation group was treated with erbesartan hydrochlorothiazide on the basis of routine treatment in the control group.The changes of vascular endothelial function,hemodynamics and inflammatory factors in the two groups were compared.Results:Before treatment,there was no significant difference invWF,EDD and NMD levels,hemodynamicslevel and CRP,ICAM-1 and MCP-1levels(P＞0.05).After treatment,the vWF levelin the observation group was significantly decreased and the EDD level was significantly increased (P ＜0.05);while the level of NMD was not significantly changed(P ＞0.05).After treatment,the level of vWF in the control group was significantly decreased(P ＜0.05);but there was no significant change in EDD and NMD level (P ＞ 0.05).After treatment,vWFlevel(144.94±16.21)％ in the observation group was significantly lower than that in the control group;EDD level (6.81±0.74)％ was significantly higher than that in the control group (P＜0.05).After treatment,the levels of LBV,HBV and PV in the observation group were significantly lower than those before treatment (P＜0.05),while the levels of LBV,HBV and PV in the control group were not significantly different from those before treatment (P ＞0.05).After treatment,LBV level (13.34±1.41) m · pas,HBV level (5.13±1.34) m · pas and PV level (1.65±0.34) m · pas in the observation group were significantly lower than those in the control group(P＜0.05).After treatment,the levels of CRP,ICAM-1 and MCP-1 in both groups were significantly lower than those before treatment (P＜0.05).After treatment,the level of CRP(1.71±0.81) mg/L,ICAM-1 level (330.82±68.51) ng/mL and MCP-1 level (3.02±1.06) g/L in the observation group were significantly lower than those in the control group (P＜0.05).Conclusion:Irbesartan hydrochlorothiazide treatment of hypertension can play a significant role in the improvement of vascular endothelial function and hemorheology in patients,and can significantly reduce the level of inflammatory response in the body,worthy of clinical application.关键词
厄贝沙坦氢氯噻嗪/高血压/血管内皮功能/血流动力学/炎症反应Key words
Irbesartan hydrochlorothiazide/Hypertension/Endothelial function/Hemodynamics/Inflammatory reaction分类
医药卫生引用本文复制引用
戈陈艳,杜林哲,张雪萌,焦娇,石婷..厄贝沙坦氢氯噻嗪对高血压患者血管内皮功能、血流动力学及炎症反应的影响[J].海南医学院学报,2018,24(8):841-844,848,5.基金项目
This study was supported by Natural Science Foundation of Jiangsu Province(Grant No.BK2015129).江苏省自然科学基金资助(BK2015129) （Grant No.BK2015129）
