海南医学院学报2018，Vol.24Issue(8)：845-848,4.DOI:10.13210/j.cnki.jhmu.20180119.002
腹腔镜手术后羟考酮与芬太尼静脉自控镇痛对疼痛程度、免疫应答及应激反应的影响
Effects of oxycodone and fentanyl patient-controlled intravenous analgesia on pain, immune response and stress response after laparoscopic surgery
摘要
Abstract
Objective:To study the effects of oxycodone and fentanyl patient-controlled intravenous analgesia on pain,immune response and stress response after laparoscopic surgery.Methods:Patients undergoing laparoscopic surgery in Xianning Central Hospital between June 2015 and February 2017 were selected and randomly divided into oxycodone group and fentanyl group who received postoperative oxycodone and fentanyl patient-controlled intravenous analgesia respectively.3 days after surgery and 5 days after surgery,the serum contents of pain-related transmitters,immune indexes,stress-related molecules as well as peripheral blood contents of immune cells were measured.Results:3 days after surgery and 5 days after surgery,CRP,TNF-α,IL-8,sICAM-1,YKL-40,Cor,C-P,FT3,FT4 and HO-1 contents in serum of oxycodone group were significantly lower than those of fentanyl group (P＜0.05) whereas CD3+ CD4+ T cell and CD3+ CD8+T cell contents in peripheral blood as well as C3 and C4 contents in serum were significantly higher than those of fentanyl group (P＜0.05).Conclusion:oxycodone patient-controlled intravenous analgesia after laparoscopic surgery is better than fentanyl and can reduce the pain degree,inhibit the stress response and improve the immune response.关键词
腹腔镜/静脉自控镇痛/羟考酮/芬太尼/应激反应/免疫应答Key words
Laparoscope/Patient-controlled intravenous analgesia/Oxycodone/fentanyl/Stress response/Immune response分类
医药卫生引用本文复制引用
廖卫宁,张郃,董文理,何金..腹腔镜手术后羟考酮与芬太尼静脉自控镇痛对疼痛程度、免疫应答及应激反应的影响[J].海南医学院学报,2018,24(8):845-848,4.基金项目
This study was supported by the Project of Xianning Municipal Center Hospital (Grant No2016XYB006).咸宁市中心医院院级项目(2016XYB006) （Grant No2016XYB006）
