海南医学院学报2018，Vol.24Issue(8)：849-852,4.DOI:10.13210/j.cnki.jhmu.20180119.001
头孢克肟对感染性肠炎小儿对全身炎症应激反应、肠黏膜屏障损伤的影响
Effects of cefixime on the systemic inflammatory stress response and intestinal mucosal barrier injury in children with infective enteritis
摘要
Abstract
Objective:To investigate the effects of cefixime on the systemic inflammatory stress response and intestinal mucosal barrier injury in children with infective enteritis.Methods:80 children with infective enteritis who were treated in the hospital between March 2016 and August 2017 were divided into group A (n =40) and group B (n =40) according to the random number table method.Group A received cefaclor anti-infective therapy,group B received cefixime therapy,and both therapies lasted for 1 week.The differences in serum levels of inflammatory mediators,oxidative stress indexes and intestinal mucosal injury markers were compared between the two groups before and after treatment.Results:Before treatment,the differences in serum levels of inflammatory mediators,oxidative stress indexes and intestinal mucosal injury markers were not statistically significant.After 1 week of treatment,serum inflammatory mediators IL-8 and TNF-α levels of group B were lower than those of group A whereas IL-10 level was higher than that of group A;serum oxidative stress indexes ROS and MDA levels were lower than those of group A whereas GSH-Px and CAT levels were higher than those of group A;serum intestinal mucosal injury markers DAO,D-Lactate,FABP and GST levels were lower than those of group A.Conclusion:Cefixime anti-infective therapy can effectively inhibit the inflammatory stress response and reduce the intestinal mucosal barrier injury in children with infective enteritis.关键词
感染性肠炎/头孢克肟/炎症反应/氧化应激/肠黏膜屏障功能Key words
infective enteritis/cefixime/inflammatory response/oxidative stress/intestinal mucosal barrier function分类
医药卫生引用本文复制引用
李玲梅,曾德润,张晓红,叶永昕..头孢克肟对感染性肠炎小儿对全身炎症应激反应、肠黏膜屏障损伤的影响[J].海南医学院学报,2018,24(8):849-852,4.基金项目
It is supported by Scientific Research Project of Panzhihua Science and Technology Bureau in 2015 (2015CY-S-23).攀枝花市2015年科技局科研项目(2015CY-S-23) （2015CY-S-23）
