海南医学院学报2018，Vol.24Issue(8)：853-856,4.DOI:10.13210/j.cnki.jhmu.20180223.013
非小细胞肺癌患者血清中GDF-15、MIF含量与癌细胞恶性行为的相关性研究
The correlation of serum GDF-15 and MIF contents with the malignant behaviors of cancer cells in patients with NSCLC
摘要
Abstract
Objective:To study the correlation of serum GDF-15 and MIF contents with the malignant behaviors of cancer cells in patients with NSCLC.Methods:Patients with non-small cell lung cancer who underwent surgical resection in Kashgar Prefecture First People's Hospital in the Xinjiang Uygur Autonomous Region between January 2015 and November 2017 were selected as lung cancer group for the research,and healthy volunteers who received physical examination in Kashgar Prefecture First People's Hospital in the Xinjiang Uygur Autonomous Region during the same period were selected as the control group.Serum was collected from the lung cancer group before surgery and from the control group during physical examination respectively to determine the contents of GDF-15 and MIF;lung cancer tissue and adjacent tissue were collected from lung cancer group after surgery to determine the expression of tumor suppressor genes,proliferation genes and invasion genes.Results:Serum GDF-15 and MIF contents of lung cancer group were significantly higher than those of control group;TCF21,Bax,GRPC5A and PTEN mRNA expression in lung cancer tissue were significantly lower than those in the adjacent tissue whereas Bcl-2,AQP4,c-myc,CyclinD1,SIRT1,CatL,MMP9,N-cadherin and Vimentin mRNA expression were significantly higher than those in adjacent tissue;serum GDF-15 and MIF contents of patients with lung cancer were negatively correlated with TCF21,Bax,GRPC5A and PTEN mRNA expression,and positively correlated with Bcl-2,AQP4,c-myc,CyclinD1,SIRT1,CatL,MMP9,N-cadherin and Vimentin mRNA expression in lung cancer tissue.Conclusion:The abnormal increase of GDF-15 and MIF in patients with NSCLC is closely related to the abnormal proliferation and invasion of cancer cells.关键词
非小细胞肺癌/生长分化因子15/巨噬细胞移动抑制因子/增殖/侵袭Key words
Non-small cell lung cancer/Growth differentiation factor 15/Macrophage migration inhibitory factor/Proliferation/Invasion分类
医药卫生引用本文复制引用
郑天明,林丽娟..非小细胞肺癌患者血清中GDF-15、MIF含量与癌细胞恶性行为的相关性研究[J].海南医学院学报,2018,24(8):853-856,4.基金项目
This study was supported by Xinjiang Uygur Autonomous Region Natural Science Fund (Grant No.201318101-8).新疆维吾尔自治区自然科学基金(201318101-8) （Grant No.201318101-8）
